Evidence map›Paper›PMID 29775679›Full record

ArticleNeuropharmacology2018

Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents.

Natalie S McGuier, Jennifer A Rinker, Reginald Cannady, Diana B Fulmer, Sara R Jones, Michaela Hoffman, Patrick J Mulholland

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Adaptations in glutathione-based redox protein signaling pathways and alcohol drinking across species.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Article
  3. KAddiction biology · 2024
    Article
  4. KJournal of pain research · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Pharmacological Manipulation of KFrontiers in physiology · 2020
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Natalie S McGuierMedical University of South Carolina, Department of Neuroscience, 67 President Street, Charleston, SC, 29425, United States.
Jennifer A RinkerMedical University of South Carolina, Department of Neuroscience, 67 President Street, Charleston, SC, 29425, United States; Medical University of South Carolina, Department of Psychiatry & Behavioral Sciences, 67 President Street, Charleston, SC, 29425, United States.
Reginald CannadyMedical University of South Carolina, Department of Neuroscience, 67 President Street, Charleston, SC, 29425, United States.
Diana B FulmerMedical University of South Carolina, Department of Neuroscience, 67 President Street, Charleston, SC, 29425, United States.
Sara R JonesWake Forest School of Medicine, Department of Physiology and Pharmacology, 1 Medical Center Boulevard, Winston Salem, NC, 27157, United States.
Michaela HoffmanMedical University of South Carolina, Department of Psychiatry & Behavioral Sciences, 67 President Street, Charleston, SC, 29425, United States.
Patrick J MulhollandMedical University of South Carolina, Department of Neuroscience, 67 President Street, Charleston, SC, 29425, United States; Medical University of South Carolina, Department of Psychiatry & Behavioral Sciences, 67 President Street, Charleston, SC, 29425, United States. Electronic address: mulholl@musc.edu.
Medical University of South Carolina · USWake Forest University · US

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Patrick J. Mulholland · 1996 to 2026
$46.8M
Wake Forest Translational Alcohol Research Center (WF-TARC)P50AA026117 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jeffrey L. Weiner · 2018 to 2026
$16.2M
Role of Kappa Opioid Receptors in Maladaptive Catecholamine Responses to Stress and Alcohol ExposureU01AA014091 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Katherine Mercedes Holleran, SARA RAULERSON JONES · 2003 to 2026
$7.7M
Kv7 channels and heavy alcohol drinkingR01AA023288 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MULHOLLAND, PATRICK J. · 2014 to 2023
$3.4M
Translational Studies on Early-life Stress and Vulnerability to Alcohol AddictionP01AA021099 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON · 2012 to 2016
$2.8M
Stress and Ethanol Dependence: SK Channels and GlutamateU01AA020930 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MULHOLLAND, PATRICK J. · 2012 to 2021
$2.6M
Ethanol Dependence Induced Changes in Dopamine Signaling in Basolateral AmygdalaR01AA023999 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON, MCCOOL, BRIAN A · 2015 to 2019
$1.8M
Dependence-Induced Excessive Ethanol Consumption: Role of Corticostriatal Kv7 ChannelsK01AA025110 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RINKER, JENNIFER ANNE · 2017 to 2021
$930k
Homer2 and Chronic Ethanol-Associated NeuroadaptationsF31AA021618 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI STRAIGHT, NATALIE M. · 2012 to 2014
$125k
NIAAA NIH HHS F31 AA021618NIAAA NIH HHS K01 AA025110NIAAA NIH HHS P01 AA021099NIAAA NIH HHS P50 AA010761NIAAA NIH HHS P50 AA026117NIAAA NIH HHS R01 AA023288NIAAA NIH HHS R01 AA023999NIAAA NIH HHS U01 AA014091NIAAA NIH HHS U01 AA020930
6 · The paper itself

Abstract

Currently available pharmacotherapies for treating alcohol use disorder (AUD) suffer from deleterious side effects and are not efficacious in diverse populations. Clinical and preclinical studies provide evidence that the Kcnq family of genes that encode K

Indexed as

Alcohol DeterrentsAlcohol DrinkingAlcohol-Related DisordersAnimalsDopamineDrug-Seeking BehaviorFemaleGenetic Predisposition to DiseaseKCNQ Potassium ChannelsMaleMiceMotor ActivityRats, WistarVentral Tegmental AreaAlcohol DeterrentsDopamineKcnq4 protein, mouseKcnq4 protein, ratKCNQ Potassium ChannelsAlcohol drinkingKcnq4K(V)7 channelsML213RetigabineVTA, ventral tegmental area

Identifiers

PMID29775679
PMCPMC6054890
OpenAlexW2805019515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.