Evidence map›Paper›PMID 29775579›Full record

ArticleMolecular cell2018

A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress.

Sophie Gay, Daniele Piccini, Christopher Bruhn, Sara Ricciardi, Paolo Soffientini, Walter Carotenuto, Stefano Biffo, Marco Foiani

Open access · hybridAbstract read
In one paragraph

Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sophie GayIFOM, The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy. Electronic address: sophie.gay@ifom.eu.
Daniele PicciniIFOM, The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
Christopher BruhnIFOM, The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
Sara RicciardiFondazione Istituto Nazionale Genetica Molecolare, Via Francesco Sforza, 32, 20122 Milan, Italy; Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.
Paolo SoffientiniIFOM, The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
Walter CarotenutoIFOM, The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
Stefano BiffoFondazione Istituto Nazionale Genetica Molecolare, Via Francesco Sforza, 32, 20122 Milan, Italy; Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.
Marco FoianiIFOM, The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy. Electronic address: marco.foiani@ifom.eu.
FIRC Institute of Molecular Oncology · ITUniversity of Milan · ITIstituto Nazionale Genetica Molecolare · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell survival to replication stress depends on the activation of the Mec1

Indexed as

DNA ReplicationMitosisProtein BiosynthesisS PhaseCell Cycle ProteinsCheckpoint Kinase 2Cyclin BCyclinsMad2 ProteinsReplication OriginRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsCaf20 protein, S cerevisiaeCell Cycle ProteinsCheckpoint Kinase 2CLB5 protein, S cerevisiaeCyclin BCyclinsMad2 ProteinsMAD2 protein, S cerevisiaeRAD53 protein, S cerevisiaeRNA, MessengerSaccharomyces cerevisiae ProteinsTranscription Factors4E-BPCaf20Clb5Clb6cyclinintra-S checkpointMad2Rad53replication originstranslation

Identifiers

PMID29775579
PMCPMC5972228
OpenAlexW2803855011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.