ArticlePLoS pathogens2018
Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Plasticity of Expression of Immunoregulatory Genes in Two Allopatric Populations of Drosophila ananassae: Novel Insight into Molecular Process Under Selection.Journal of molecular evolution · 2026Article
- Oxytocin Affects Barriergenesis in the Blood-Brain Barrier and the Blood-Cerebrospinal Fluid Barrier In Vitro Monoculture Transwell Models.Developmental neurobiology · 2026Article
- Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity.Molecular oncology · 2026Article
- Proteomic networks and related genetic variants associated with smoking and chronic obstructive pulmonary disease.BMC genomics · 2024Article
- PXDN as a pan-cancer biomarker and promotes tumor progress via immune inhibition in nasopharyngeal carcinoma.Frontiers in oncology · 2024Article
- Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks.BMC genomics · 2022Article
- Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage.NPJ Regenerative medicine · 2022Article
- Mammalian peroxidasin (PXDN): From physiology to pathology.Free radical biology & medicine · 2022Review
- Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents.Microbiology spectrum · 2022Article
- Functional Characterization of Organoids Derived From Irreversibly Damaged Liver of Patients With NASH.Hepatology (Baltimore, Md.) · 2021Article
- Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix.The Journal of biological chemistry · 2020Article
- Severe Infection in Anti-Glomerular Basement Membrane Disease: A Retrospective Multicenter French Study.Journal of clinical medicine · 2020Article
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Authors and funding
7 authors.
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Abstract
Innate immune recognition is classically mediated by the interaction of host pattern-recognition receptors and pathogen-associated molecular patterns; this triggers a series of downstream signaling events that facilitate killing and elimination of invading pathogens. In this report, we provide the first evidence that peroxidasin (PXDN; also known as vascular peroxidase-1) directly binds to gram-negative bacteria and mediates bactericidal activity, thus, contributing to lung host defense. PXDN contains five leucine-rich repeats and four immunoglobulin domains, which allows for its interaction with lipopolysaccharide, a membrane component of gram-negative bacteria. Bactericidal activity of PXDN is mediated via its capacity to generate hypohalous acids. Deficiency of PXDN results in a failure to eradicate Pseudomonas aeruginosa and increased mortality in a murine model of Pseudomonas lung infection. These observations indicate that PXDN mediates previously unrecognized host defense functions against gram-negative bacterial pathogens.
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