ArticlePloS one2018
Maternal asthma is associated with increased risk of perinatal mortality.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Asthma Control During Pregnancy and Adverse Perinatal Outcomes: A Systematic Review.The Australian & New Zealand journal of obstetrics & gynaecology · 2026Pooled it
- Obesity and asthma during pregnancy: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Effect of asthma management with exhaled nitric oxideThe European respiratory journal · 2022Trial
- Atherogenic index of plasma predicts gestational diabetes mellitus and correlates with disease severity and adverse pregnancy outcomes.Journal of endocrinological investigation · 2026Article
- "Actionable" risk for preterm birth: patterns and prediction in California singleton births 2016-2020.BMC pregnancy and childbirth · 2026Article
- Maternal asthma and the role of stress, sensitization, and lung function on pregnancy outcomes: MAESTRO cohort study.The journal of allergy and clinical immunology. Global · 2026Article
- Prevalence and maternal risk factors of small for gestational age infants born at a regional centre in Australia: a retrospective study.Translational pediatrics · 2025Article
- Child-focused climate change and health content in medical schools and pediatric residencies.Pediatric research · 2025Review
- Association of maternal asthma with congenital heart defects in offspring.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Maternal asthma during pregnancy and the likelihood of neurodevelopmental disorders in offspring.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Addressing uncertainty in identifying pregnancies in the English CPRD GOLD Pregnancy Register: a methodological study using a worked example.International journal of population data science · 2025Article
- Factors affecting asthma control in pregnancy: A cross-sectional study.Pakistan journal of medical sciences · 2024Article
- Evaluating the effect of maternal non-communicable disease on adverse pregnancy outcomes and birthweight in Pakistan, a facility based retrospective cohort study.Scientific reports · 2024Article
- Non-allergic factors that influence asthma control in pregnancy.European journal of midwifery · 2024Article
- Review
- Maternal asthma in relation to infant size and body composition.The journal of allergy and clinical immunology. Global · 2023Article
- The Role of Climate Change in Asthma.Advances in experimental medicine and biology · 2023Article
- Asthma in pregnancy.Allergy and asthma proceedings · 2023Review
- Breast milk-derived extracellular vesicle miRNAs are associated with maternal asthma and atopy.Epigenomics · 2022Article
- Challenges in the successful management of asthma during conception, pregnancy and delivery.Breathe (Sheffield, England) · 2022Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome.
objectivesOur goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication.
methodsThe study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93.3%) pregnancies in mothers with neither confirmed asthma nor use of asthma medication (controls), and 26 674 (2.8%) pregnancies with confirmed maternal asthma. 71% of mothers with asthma used asthma medication. The diagnosis of asthma was based on the mothers' right for subsidised medication which is carefully evaluated by strict criteria including pulmonary function testing. Odds ratio was used in comparison. Premature birth (PB), low birth weight, small for gestational age (SGA), neonatal death were the main outcome measures.
resultsMaternal asthma was associated with adjusted odds ratios (aORs) for perinatal mortality 1.24 (95% CI 1.05 to 1.46), preterm birth 1.18 (1.11 to 1.25), low birth weight 1.29 (1.21 to 1.37), fetal growth restriction (SGA) 1.32, (1.24 to 1.40), and asphyxia 1.09 (1.02 to 1.17). Asthma treatment reduced the increased risk of preterm birth aOR 0.85 (95% CI 0.76 to 0.96) but mothers with treated asthma had higher risks of fetal growth restriction (SGA) aOR 1.26 (1.10 to 1.45), and asphyxia aOR 1.37 (1.17 to 1.61) than mothers with untreated asthma.
conclusionAsthma is associated with increased risks of perinatal mortality, preterm birth, low birth weight, fetal growth restriction (SGA), and asphyxia. Asthma treatment reduces the risk of preterm delivery, but it does not seem to reduce other complications such as perinatal mortality.
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Registered trials
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