ArticlePLoS computational biology2018
Potassium and sodium microdomains in thin astroglial processes: A computational model study.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms.eLife · 2026Article
- The Role of the Glutamate-Glutamine Cycle in Synaptic Transmission During Ischemia and Recovery.The European journal of neuroscience · 2026Article
- Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation.PLoS computational biology · 2026Article
- Cellular and subcellular heterogeneity of astrocytic Na⁺ homeostasis tuning astrocytes into functionally distinct subgroups in the mouse brain.Nature communications · 2026Article
- Modular Model of Neuronal Activity That Captures the Dynamics of Main Molecular Targets of Antiepileptic Drugs.International journal of molecular sciences · 2026Article
- Central Neurophysiological Alterations in Dystrophic mdx Mice Correlate With Reduced Hippocampal Levels of the Endogenous NMDA Receptor Ligand D-Aspartate.Journal of neurochemistry · 2025Article
- Deficient Astrocyte Homeostatic Support Contributes to Brain Impairment in Duchenne Muscular Dystrophy.Neurochemical research · 2025Review
- Atypical plume-like events contribute to glutamate accumulation in metabolic stress conditions.iScience · 2025Article
- The Duality of Astrocyte Neuromodulation: Astrocytes Sense Neuromodulators and Are Neuromodulators.Journal of neurochemistry · 2025Review
- Unveiling the functional connectivity of astrocytic networks with AstroNet, a graph reconstruction algorithm coupled to image processing.Communications biology · 2025Article
- An Empirical-Theoretical Approach to Determine Astroglial Potassium Upon Ischemic Stress.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model.Molecular neurobiology · 2024Article
- Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms.Molecular neurodegeneration · 2023Review
- The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses.Scientific reports · 2023Article
- Antidepressant mechanisms of ketamine: a review of actions with relevance to treatment-resistance and neuroprogression.Frontiers in neuroscience · 2023Review
- Changes in Astroglial KInternational journal of molecular sciences · 2022Article
- Rac1 Signaling in Amygdala Astrocytes Regulates Fear Memory Acquisition and Retrieval.Neuroscience bulletin · 2021Article
- Ketamine Alters Functional Plasticity of Astroglia: An Implication for Antidepressant Effect.Life (Basel, Switzerland) · 2021Review
- Ion dynamics at the energy-deprived tripartite synapse.PLoS computational biology · 2021Article
- Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain.Pflugers Archiv : European journal of physiology · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A biophysical model that captures molecular homeostatic control of ions at the perisynaptic cradle (PsC) is of fundamental importance for understanding the interplay between astroglial and neuronal compartments. In this paper, we develop a multi-compartmental mathematical model which proposes a novel mechanism whereby the flow of cations in thin processes is restricted due to negatively charged membrane lipids which result in the formation of deep potential wells near the dipole heads. These wells restrict the flow of cations to "hopping" between adjacent wells as they transverse the process, and this surface retention of cations will be shown to give rise to the formation of potassium (K+) and sodium (Na+) microdomains at the PsC. We further propose that a K+ microdomain formed at the PsC, provides the driving force for the return of K+ to the extracellular space for uptake by the neurone, thereby preventing K+ undershoot. A slow decay of Na+ was also observed in our simulation after a period of glutamate stimulation which is in strong agreement with experimental observations. The pathological implications of microdomain formation during neuronal excitation are also discussed.
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