ArticleAmerican journal of physiology. Heart and circulatory physiology2018
Venoarterial communication mediates arterial wall shear stress-induced maternal uterine vascular remodeling during pregnancy.
Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and hemodynamic factors.American journal of physiology. Heart and circulatory physiology · 2023Article
- Piezo1 channels mediate vasorelaxation of uterine arteries from pseudopregnant rats.Frontiers in physiology · 2023Article
- Evidence of Nitric Oxide Impairment During Hypertensive Pregnancies.Advances in experimental medicine and biology · 2023Review
- Feasibility of Vascular Parameter Estimation for Assessing Hypertensive Pregnancy Disorders.Journal of biomechanical engineering · 2022Article
- Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia.Frontiers in cell and developmental biology · 2022Review
- Normalization of wall shear stress as a physiological mechanism for regulating maternal uterine artery expansive remodeling during pregnancy.FASEB bioAdvances · 2021Article
- Preeclampsia Is a Syndrome with a Cascade of Pathophysiologic Events.Journal of clinical medicine · 2020Review
- Enhanced Vascular Smooth Muscle Calcium Sensitivity and Loss of Endothelial Vasodilator Influence Contribute to Myogenic Tone Development in Rat Radial Uterine Arteries during Gestation.Journal of vascular research · 2020Article
- Developmental onset of cardiovascular disease-Could the proof be in the placenta?Microcirculation (New York, N.Y. : 1994) · 2019Review
- Emerging concepts of shear stress in placental development and function.Molecular human reproduction · 2019Article
- Plasticity of the Maternal Vasculature During Pregnancy.Annual review of physiology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Although expansive remodeling of the maternal uterine circulation during pregnancy is essential for maintaining uteroplacental perfusion and normal fetal growth, the underlying physiological mechanisms are not well understood. Using a rat model, surgical approaches were used to alter uterine hemodynamics and wall shear stress (WSS) to evaluate the effects of WSS and venoarterial communication (e.g., transfer of placentally derived growth signals from postplacental veins to preplacental arteries) on gestational uterine vascular remodeling. Changes in WSS secondary to ligation of the cervical but not the ovarian end of the main uterine artery and vein provoked significant expansive remodeling at the opposite end of both vessels, but only in pregnant animals. The ≈50% increase in lumen diameter (relative to the contralateral horn) was associated with an upregulation of total endothelial nitric oxide (NO) synthase expression and was abolished by in vivo NO synthase inhibition with N-nitro-l-arginine methyl ester. Complete removal of a venous segment adjacent to the uterine artery to eliminate local venous influences significantly attenuated the WSS-induced remodeling by about one-half ( P < 0.05). These findings indicate that, during pregnancy, 1) increased WSS stimulates uterine artery growth via NO signaling and 2) the presence of an adjacent vein is required for arterial remodeling to fully occur. NEW & NOTEWORTHY This study provides the first in vivo evidence for the importance of venous influences on arterial growth within the uteroplacental circulation.
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