Evidence map›Paper›PMID 29775407›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Effect of healthy aging and sex on middle cerebral artery blood velocity dynamics during moderate-intensity exercise.

Jaimie L Ward, Jesse C Craig, Yumei Liu, Eric D Vidoni, Rebecca Maletsky, David C Poole, Sandra A Billinger

Registry-linked trialAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05131217 (Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05131217 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults

TypeinterventionalSponsorUniversity of VirginiaRan2022 to 2023Enrolled13ConditionsAging WellArmsAcute bout of Continuous Moderate Intensity Exercise, Acute bout of High Intensity Interval Training, Control
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  8. APOE4 carriers display loss of anticipatory cerebrovascular regulation across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Article
  10. Review
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  13. Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  14. The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  15. Habitual exercise in youth: A 'brainy' idea.Experimental physiology · 2023
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jaimie L WardDepartment of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center , Kansas City, Kansas.
Jesse C CraigDepartment of Kinesiology and Department of Anatomy and Physiology, Kansas State University , Manhattan, Kansas.ORCID 0000-0001-5959-4139
Yumei LiuDepartment of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center , Kansas City, Kansas.
Eric D VidoniUniversity of Kansas Alzheimer's Disease Center, Fairway, Kansas.
Rebecca MaletskyLawrence, Kansas.
David C PooleDepartment of Kinesiology and Department of Anatomy and Physiology, Kansas State University , Manhattan, Kansas.
Sandra A BillingerDepartment of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center , Kansas City, Kansas.

Funding

University of Kansas Alzheimer's Disease Research Center (KU ADRC)P30AG072973 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mohammad Haeri · 2021 to 2026
$25.3M
University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SWERDLOW, RUSSELL H. · 2011 to 2020
$16.6M
Heartland Institute for Clinical and Translational ResearchUL1TR000001 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2012 to 2015
$13.0M
Examining Vascular Regulation Following Acute StrokeK01HD067318 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BILLINGER, SANDRA A · 2011 to 2015
$505k
NCATS NIH HHS UL1 TR000001NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG072973NICHD NIH HHS K01 HD067318
6 · The paper itself

Abstract

Blood velocity measured in the middle cerebral artery (MCA

Indexed as

ExerciseHemodynamicsAdultAgedAged, 80 and overAgingCerebrovascular CirculationFemaleHumansMaleMiddle Cerebral ArterySex Factorsagingcerebral blood flowdynamic blood flow responsesex differences

Identifiers

PMID29775407
PMCPMC6172645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.