ArticleJournal of the American Chemical Society2018
Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Force-modulated and strain-dependent stereoselectivity of copper-catalyzed reductive coupling.Chemical science · 2026Article
- Enantio- and Site-Selective Synthesis of α-Substituted Hydrazines, Pyrazolidines, and Tertiary Alcohols by Copper-Catalyzed Allylic C-N and C-O Bond Formation.Journal of the American Chemical Society · 2026Article
- Preparation of 1,4-Diamines by Enantio- and Diastereoselective Cu-Josiphos-Catalyzed Reductive Couplings of Azatrienes and Imines: Regiodivergence Enabled by Catalyst Structure and Reagent Tailoring.Journal of the American Chemical Society · 2025Article
- Azocarboxamide-enabled enantioselective regiodivergent unsymmetrical 1,2-diaminations.Nature communications · 2024Article
- Chemoselective Diazine Dearomatization: The Catalytic Enantioselective Dearomatization of Pyrazine.Journal of the American Chemical Society · 2024Article
- Intermolecular Hydroalkoxylation and Hydrocarboxylation of 2-Azadienes with High Efficiency.The Journal of organic chemistry · 2023Article
- Diastereo- and Enantioselective Reductive Mannich-type Reaction of α,β-Unsaturated Carboxylic Acids to Ketimines: A Direct Entry to Unprotected βChemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Transition-metal free C-N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer.Nature communications · 2022Article
- α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes.Chemical science · 2022Article
- A Diastereodivergent and Enantioselective Approach toJournal of the American Chemical Society · 2021Article
- Synthesis of 1,2-Aminoalcohols through Enantioselective Aminoallylation of Ketones by Cu-Catalyzed Reductive Coupling.Organic letters · 2021Article
- CuH-Catalyzed Regio- and Enantioselective Hydrocarboxylation of Allenes: Toward Carboxylic Acids with Acyclic Quaternary Centers.Journal of the American Chemical Society · 2021Article
- Access to Chiral Diamine Derivatives through Stereoselective Cu-Catalyzed Reductive Coupling of Imines and Allenamides.The Journal of organic chemistry · 2021Article
- Nickel-catalyzed enantioselective vinylation of aryl 2-azaallyl anions.Chemical science · 2021Article
- Synthesis of an elusive, stable 2-azaallyl radical guided by electrochemical and reactivity studies of 2-azaallyl anions.Chemical science · 2021Article
- Synthesis of chiral anti-1,2-diamine derivatives through copper(I)-catalyzed asymmetric α-addition of ketimines to aldimines.Nature communications · 2020Article
- CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition.Accounts of chemical research · 2020Article
- Highly Enantioselective Synthesis of Indazoles with a C3-Quaternary Chiral Center Using CuH Catalysis.Journal of the American Chemical Society · 2020Article
- Enantio- and Diastereoselective Synthesis of Homopropargyl Amines by Copper-Catalyzed Coupling of Imines, 1,3-Enynes, and Diborons.Angewandte Chemie (International ed. in English) · 2020Article
- Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes.Organic letters · 2020Article
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3 authors.
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Abstract
Here we report highly efficient and chemoselective azadiene-imine reductive couplings catalyzed by (Ph-BPE)Cu-H that afford anti-1,2-diamines. In all cases, reactions take place with either aldimine or ketimine electrophiles to deliver a single diastereomer of product in >95:5 er. The products' diamines are easily differentiable, facilitating downstream synthesis.
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