Evidence map›Paper›PMID 29775114›Full record

Observational studyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury.

Gemma Bale, Subhabrata Mitra, Isabel de Roever, Magdalena Sokolska, David Price, Alan Bainbridge, Roxana Gunny, Cristina Uria-Avellanal, Giles S Kendall, Judith Meek and 2 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Hemodynamics in infants with hypoxemic ischemic encephalopathy: pathophysiology and beyond.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
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  19. Effects of O-GlcNAcylation on functional mitochondrial transfer from astrocytes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  20. Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Gemma BaleDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Subhabrata MitraInstitute of Women's Health, University College London, London, UK.
Isabel de RoeverDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Magdalena SokolskaDepartment of Medical Physics and Biomedical Engineering, University College London Hospital, London, UK.
David PriceDepartment of Medical Physics and Biomedical Engineering, University College London Hospital, London, UK.
Alan BainbridgeDepartment of Medical Physics and Biomedical Engineering, University College London Hospital, London, UK.
Roxana GunnyPaediatric Neuroradiology, Great Ormond Street Hospital for Children, London, UK.
Cristina Uria-AvellanalInstitute of Women's Health, University College London, London, UK.
Giles S KendallNeonatal Unit, University College London Hospital, London, UK.
Judith MeekInstitute of Women's Health, University College London, London, UK.
Nicola J RobertsonInstitute of Women's Health, University College London, London, UK.
Ilias TachtsidisDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
University College London · GBLondon Women's Clinic · GBUniversity College Hospital · GBGreat Ormond Street Hospital · GB

Funding

Department of HealthWellcome Trust 088429/Z/09/ZWellcome Trust 104580/Z/14/Z
6 · The paper itself

Abstract

There is a need for a method of real-time assessment of brain metabolism during neonatal hypoxic-ischaemic encephalopathy (HIE). We have used broadband near-infrared spectroscopy (NIRS) to monitor cerebral oxygenation and metabolic changes in 50 neonates with HIE undergoing therapeutic hypothermia treatment. In 24 neonates, 54 episodes of spontaneous decreases in peripheral oxygen saturation (desaturations) were recorded between 6 and 81 h after birth. We observed differences in the cerebral metabolic responses to these episodes that were related to the predicted outcome of the injury, as determined by subsequent magnetic resonance spectroscopy derived lactate/N-acetyl-aspartate. We demonstrated that a strong relationship between cerebral metabolism (broadband NIRS-measured cytochrome-c-oxidase (CCO)) and cerebral oxygenation was associated with unfavourable outcome; this is likely to be due to a lower cerebral metabolic rate and mitochondrial dysfunction in severe encephalopathy. Specifically, a decrease in the brain tissue oxidation state of CCO greater than 0.06 µM per 1 µM brain haemoglobin oxygenation drop was able to predict the outcome with 64% sensitivity and 79% specificity (receiver operating characteristic area under the curve = 0.73). With further work on the implementation of this methodology, broadband NIRS has the potential to provide an early, cotside, non-invasive, clinically relevant metabolic marker of perinatal hypoxic-ischaemic injury.

Indexed as

Hypothermia, InducedBrainBrain InjuriesCerebrovascular CirculationFemaleHumansHypoxiaInfant, NewbornMaleMitochondriaOxygenProspective StudiesTreatment OutcomeOxygenCerebral haemodynamicsmetabolismmitochondrianear-infrared spectroscopyperinatal hypoxia

Identifiers

PMID29775114
PMCPMC6775592
OpenAlexW2803488946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.