Evidence map›Paper›PMID 29775058›Full record

ArticleJournal of the American Chemical Society2018

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.

Andrew C Yang, Haley du Bois, Niclas Olsson, David Gate, Benoit Lehallier, Daniela Berdnik, Kyle D Brewer, Carolyn R Bertozzi, Joshua E Elias, Tony Wyss-Coray

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Haley du Bois
Niclas Olsson
David Gate
Benoit Lehallier
Daniela BerdnikCenter for Tissue Regeneration, Repair and Restoration , V.A. Palo Alto Healthcare System , Palo Alto , California 94304 , United States.
Kyle D Brewer
Carolyn R BertozziORCID 0000-0003-4482-2754
Joshua E Elias
Tony Wyss-CorayCenter for Tissue Regeneration, Repair and Restoration , V.A. Palo Alto Healthcare System , Palo Alto , California 94304 , United States.
Stanford University · USVA Palo Alto Health Care System · USHoward Hughes Medical Institute · US

Funding

Metabolic Engineering with Bioorthogonal Chemical ReportersR37GM058867 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BERTOZZI, CAROLYN · 2009 to 2018
$4.7M
A Bioorthogonal Approach to Study Mammalian AgingDP1AG053015 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2015 to 2019
$3.7M
Stanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2M
BLRD VA IK6 BX004599Howard Hughes Medical InstituteNIA NIH HHS DP1 AG053015NIGMS NIH HHS R37 GM058867NIGMS NIH HHS T32 GM120007
6 · The paper itself

Abstract

Bioorthogonal tools enable cell-type-specific proteomics, a prerequisite to understanding biological processes in multicellular organisms. Here we report two engineered aminoacyl-tRNA synthetases for mammalian bioorthogonal labeling: a tyrosyl ( ScTyr

Indexed as

AlkynesAmino AcidsAnimalsAzidesBase SequenceCHO CellsClick ChemistryCricetulusCycloaddition ReactionFemaleHEK293 CellsHumansMethionine-tRNA LigaseMiceMice, Inbred C57BLMutationAlkynesAmino AcidsAzidesMethionine-tRNA LigaseProteomeTyrosine-tRNA Ligase

Identifiers

PMID29775058
PMCPMC6598694
OpenAlexW2804618544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.