ArticleJournal of cachexia, sarcopenia and muscle2018
Searching for a mitochondrial root to the decline in muscle function with ageing.
Article in Journal of cachexia, sarcopenia and muscle, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effects of Glucagon-Like Peptide-1 Receptor Agonists on Mitochondrial Function Within Skeletal Muscle: A Systematic Review.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Metabolomic profiles of being physically active and less sedentary: a critical review.Metabolomics : Official journal of the Metabolomic Society · 2021Pooled it
- A High Geriatric Depression Scale Score on Admission to Hospital Predicts a Worse Clinical Frailty Scale Score After Discharge.Geriatrics & gerontology international · 2026Article
- Gender Differences in Circulating TFAM Levels Are Associated with Functional Impairment and Sarcopenia.Biomedicines · 2026Article
- Astaxanthin improves myogenicity of aged skeletal muscle progenitor cells in a sexually dimorphic manner.npj aging · 2026Article
- Leveraging mitochondrial stress to improve healthy aging.Sports medicine and health science · 2026Review
- Exploring the relationship between cognitive function and frailty in middle-aged and older adults Chinese adults: evidence from the CHARLS database.Frontiers in public health · 2026Article
- Longitudinal association of intensity-specific physical activity and sedentary behavior with dynapenia among older Taiwanese adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise.Antioxidants (Basel, Switzerland) · 2025Article
- Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics.Molecules (Basel, Switzerland) · 2025Article
- Deconditioning in quiescent Crohn's disease patients with heightened fatigue perception.Journal of Crohn's & colitis · 2025Article
- Exploration of Pathogenesis and Cutting-Edge Treatment Strategies of Sarcopenia: A Narrative Review.Clinical interventions in aging · 2025Review
- Nutrient Metabolites Associated With Low D3Cr Muscle Mass, Strength, and Physical Performance in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- A mito-centric view on muscle aging and function.Frontiers in public health · 2023Article
- Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD.The European respiratory journal · 2022Article
- Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans.Frontiers in bioengineering and biotechnology · 2022Article
- Linoleic Acid Intake and Physical Function: Pilot Results from the Health ABC Energy Expenditure Sub-Study.Advances in geriatric medicine and research · 2022Article
- Association between height-related polymorphism rs17081935 and reduced handgrip strength in relation to status of atherosclerosis: a cross-sectional study.Environmental health and preventive medicine · 2021Article
- Heterochronic Parabiosis: Old Blood Induces Changes in Mitochondrial Structure and Function of Young Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan inAntioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia, the age-related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive function, and mortality. Preventing sarcopenia may reduce the burden of functional decline with aging and its impact on physiological and economic well-being in older adults. Mitochondria in muscle cells lose their intrinsic efficiency and capacity to produce energy during aging, and it has been hypothesized that such a decline is the main driver of sarcopenia. Oxidative phosphorylation becomes impaired with aging, affecting muscle performance, and contributing to an age-associated decline in mobility. However, it is unclear whether this deterioration is due to a reduced mitochondria population, decreased mitochondrial energetic efficiency, or a reduced capacity to dynamically transport oxygen and nutrients into the mitochondria, and addressing these questions is an active area of research. Further research in humans will require use of new "omics" technologies, progress in neuroimaging techniques that permit energy production assessment, and visualization of molecules critical for energetic metabolism, as well as proxy biomarkers of muscle perfusion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.