Evidence map›Paper›PMID 29774988›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2018

Differences in primary cardiovascular disease prevention between the 2013 and 2016 cholesterol guidelines and impact of the 2017 hypertension guideline in the United States.

Brent M Egan, Jiexiang Li, Robert A Davis, Kevin A Fiscella, Jonathan N Tobin, Daniel W Jones, Angelo Sinopoli

Abstract readComparative Study
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brent M EganCare Coordination Institute, Greenville, SC, USA.ORCID 0000-0002-1470-5875
Jiexiang LiCare Coordination Institute, Greenville, SC, USA.
Robert A DavisCare Coordination Institute, Greenville, SC, USA.
Kevin A FiscellaDepartment of Family Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Jonathan N TobinClinical Directors Network (CDN), New York, NY, USA.
Daniel W JonesDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Angelo SinopoliCare Coordination Institute, Greenville, SC, USA.

Funding

Blood Pressure-Visit Intensification for Successful Improvement of TreatmentR18HL117801 · NHLBI · UNIVERSITY OF ROCHESTER · PI FISCELLA, KEVIN ANTHONY, TOBIN, JONATHAN N · 2013 to 2017
$3.3M
N2: Building a Network of Safety Net PBRNsP30HS021667 · AHRQ · CLINICAL DIRECTORS NETWORK, INC. · PI TOBIN, JONATHAN N · 2012 to 2016
$595k
AHRQ HHS P30 HS021667NHLBI NIH HHS R18 HL117801
6 · The paper itself

Abstract

The US Preventive Services Task Force cholesterol guideline recommended statins for fewer adults than the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline by setting a higher 10-year atherosclerotic cardiovascular disease threshold (≥10.0% vs ≥7.5%) and requiring concomitant diabetes mellitus, hypertension, dyslipidemia, or cigarette smoking. The 2017 ACC/AHA hypertension guideline lowered the hypertension threshold, increasing 2016 guideline statin-eligible adults. Cross-sectional data on US adults aged 40 to 75 years enabled estimated numbers for the 2013 guideline and 2016 guideline with hypertension thresholds of ≥140/≥90 mm Hg and ≥130/80 mm Hg, respectively, on: (1) untreated, statin-eligible adults for primary atherosclerotic cardiovascular disease prevention (25.40, 14.72, 15.35 million); (2) atherosclerotic cardiovascular disease events prevented annually (124 000, 70 852, 73 199); (3) number needed to treat (21, 21, 21); and (4) number needed to harm (38, 143, 143) per 1000 patient-years for incident diabetes mellitus (42 800, 6700, 7100 cases per year). Despite the lower hypertension threshold, the 2013 cholesterol guideline qualifies approximately 10 million more adults for statins and prevents approximately 50 600 more primary atherosclerotic cardiovascular disease events but induces approximately 35 700 more diabetes mellitus cases annually than the 2016 guideline.

Indexed as

AdultAdvisory CommitteesAgedCardiovascular DiseasesCholesterolCross-Sectional StudiesFemaleHumansHypertensionMaleMiddle AgedPractice Guidelines as TopicPrimary PreventionTreatment OutcomeUnited StatesCholesterolatherosclerotic cardiovascular diseasecholesterol guidelineincident diabetes mellituspreventionstatins

Identifiers

PMID29774988
PMCPMC8031287

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.