Evidence map›Paper›PMID 29774974›Full record

ReviewNMR in biomedicine2018

Stiffness reconstruction methods for MR elastography.

Daniel Fovargue, David Nordsletten, Ralph Sinkus

Abstract readReview
In one paragraph

Review in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance.Journal of experimental & clinical cancer research : CR · 2026
    Review
  3. Correlation Between Breast Parenchymal Stiffness Measured by 3T Magnetic Resonance Elastography and CT-Derived Hounsfield Units.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. A Versatile MR Elastography Research Tool with a Modified Motion Signal-to-noise Ratio Approach.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Article
  9. Review
  10. Physics-Informed Neural Networks for Tissue Elasticity Reconstruction in Magnetic Resonance Elastography.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. MR elastography: Principles, guidelines, and terminology.Magnetic resonance in medicine · 2021
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel FovargueImaging Sciences & Biomedical Engineering, King's College London, London, UK.ORCID 0000-0002-9303-8491
David NordslettenImaging Sciences & Biomedical Engineering, King's College London, London, UK.
Ralph SinkusImaging Sciences & Biomedical Engineering, King's College London, London, UK.

Funding

British Council under the Newton Fund Institutional Links ID 172707526Engineering and Physical Sciences Research Council EP/N011554/1Engineering and Physical Sciences Research Council Healthcare Technology Challenge Award EP/R003866/1European Union's Horizon 2020 Research and Innovation Programme 668039Wellcome/EPSRC Centre for Medical Engineering at Kings College London WT 203148/Z/16/ZWellcome Trust
6 · The paper itself

Abstract

Assessment of tissue stiffness is desirable for clinicians and researchers, as it is well established that pathophysiological mechanisms often alter the structural properties of tissue. Magnetic resonance elastography (MRE) provides an avenue for measuring tissue stiffness and has a long history of clinical application, including staging liver fibrosis and stratifying breast cancer malignancy. A vital component of MRE consists of the reconstruction algorithms used to derive stiffness from wave-motion images by solving inverse problems. A large range of reconstruction methods have been presented in the literature, with differing computational expense, required user input, underlying physical assumptions, and techniques for numerical evaluation. These differences, in turn, have led to varying accuracy, robustness, and ease of use. While most reconstruction techniques have been validated against in silico or in vitro phantoms, performance with real data is often more challenging, stressing the robustness and assumptions of these algorithms. This article reviews many current MRE reconstruction methods and discusses the aforementioned differences. The material assumptions underlying the methods are developed and various approaches for noise reduction, regularization, and numerical discretization are discussed. Reconstruction methods are categorized by inversion type, underlying assumptions, and their use in human and animal studies. Future directions, such as alternative material assumptions, are also discussed.

Indexed as

Elasticity Imaging TechniquesMagnetic Resonance ImagingAlgorithmsAnimalsBiomechanical PhenomenaBrainHumansLiver Cirrhosisinverse problemMR elastographyreconstructionreviewshear-modulus tissue stiffness

Identifiers

PMID29774974
PMCPMC6175248

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.