Evidence map›Paper›PMID 29774862›Full record

ArticleEmerging infectious diseases2018

Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments.

Jessica A Belser, Wendy Barclay, Ian Barr, Ron A M Fouchier, Ryota Matsuyama, Hiroshi Nishiura, Malik Peiris, Charles J Russell, Kanta Subbarao, Huachen Zhu and 1 more

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

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  16. Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary potential.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Ventilation does not affect close-range transmission of influenza virus in a ferret playpen setup.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica A Belser
Wendy Barclay
Ian Barr
Ron A M Fouchier
Ryota Matsuyama
Hiroshi Nishiura
Malik Peiris
Charles J Russell
Kanta Subbarao
Huachen Zhu
Hui-Ling Yen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment studies of novel and emerging influenza viruses. To streamline interpretation of data generated in different laboratories, we provide a consensus on experimental parameters that define risk-assessment experiments of influenza virus transmissibility, including disclosure of variables known or suspected to contribute to experimental variability in this model, and advocate adoption of more standardized practices. We also discuss current limitations of the ferret transmission model and highlight continued refinements and advances to this model ongoing in laboratories. Understanding, disclosing, and standardizing the critical parameters of ferret transmission studies will improve the comparability and reproducibility of pandemic influenza risk assessment and increase the statistical power and, perhaps, accuracy of this model.

Indexed as

FerretsAnimalsDisease Models, AnimalHumansInfluenza, HumanOrthomyxoviridaeOrthomyxoviridae InfectionsPublic Health SurveillanceRisk Assessmentferretsinfluenzapandemicsrisk assessmenttransmissionviruses

Identifiers

PMID29774862
PMCPMC6004870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.