Evidence map›Paper›PMID 29774858›Full record

ArticleEmerging infectious diseases2018

Genomic Epidemiology of Global Carbapenemase-Producing Enterobacter spp., 2008-2014.

Gisele Peirano, Yasufumi Matsumura, Mark D Adams, Patricia Bradford, Mary Motyl, Liang Chen, Barry N Kreiswirth, Johann D D Pitout

Open access · diamondAbstract readHistorical Article
In one paragraph

Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 149 citations in OpenAlex.

  1. Article
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  5. Genomic characterization ofMicrobiology spectrum · 2026
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  11. Aztreonam plus ceftazidime/avibactam broth disk elution test: failure to detect Escherichia coli with PBP-3 insertions.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  12. Article
  13. Article
  14. Molecular epidemiology of global carbapenemase-producing Serratia spp. (2015-2017).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  15. Article
  16. Article
  17. Article
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  19. Observational
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Gisele Peirano
Yasufumi Matsumura
Mark D Adams
Patricia Bradford
Mary Motyl
Liang Chen
Barry N Kreiswirth
Johann D D Pitout
Jackson Laboratory · USRutgers, The State University of New Jersey · USAstraZeneca (United States) · USJ. Craig Venter Institute · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of Pretoria · ZA

Funding

The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI TAN, GENE · 2014 to 2018
$29.7M
The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
Genomic variation in epidemic carbapenem-resistant K.pneumoniaeR21AI117338 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHEN, LIANG · 2016 to 2017
$437k
NIAID NIH HHS R01 AI090155NIAID NIH HHS R21 AI117338NIAID NIH HHS U19 AI110819
6 · The paper itself

Abstract

We performed whole-genome sequencing on 170 clinical carbapenemase-producing Enterobacter spp. isolates collected globally during 2008-2014. The most common carbapenemase was VIM, followed by New Delhi metallo-β-lactamase (NDM), Klebsiella pneumoniae carbapenemase, oxacillin 48, and IMP. The isolates were of predominantly 2 species (E. xiangfangensis and E. hormaechei subsp. steigerwaltii) and 4 global clones (sequence type [ST] 114, ST93, ST90, and ST78) with different clades within ST114 and ST90. Particular genetic structures surrounding carbapenemase genes were circulating locally in various institutions within the same or between different STs in Greece, Guatemala, Italy, Spain, Serbia, and Vietnam. We found a common NDM genetic structure (NDM-GE-U.S.), previously described on pNDM-U.S. from Klebsiella pneumoniae ATCC BAA-214, in 14 different clones obtained from 6 countries spanning 4 continents. Our study highlights the importance of surveillance programs using whole-genome sequencing in providing insight into the molecular epidemiology of carbapenemase-producing Enterobacter spp.

Indexed as

Genome, BacterialGenomicsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesDrug Resistance, BacterialEnterobacterEnterobacteriaceae InfectionsGlobal HealthHistory, 21st CenturyHumansMicrobial Sensitivity TestsMolecular EpidemiologyPhylogenyPlasmidsPolymorphism, Single NucleotideAnti-Bacterial AgentsBacterial Proteinsbeta-lactamase NDM-1beta-Lactamasescarbapenemaseantimicrobial resistancebacteriacarbapenemasesEnterobacteriaceaeEnterobacter spp.genomic epidemiologysurveillance

Identifiers

PMID29774858
PMCPMC6004858
OpenAlexW2800524745

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.