ArticleJournal of biomedical optics2018
Glucose-sensitive silicone hydrogel contact lens toward tear glucose monitoring.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Optical Contact Lenses Biosensors.ACS sensors · 2025Review
- First Design of a Contact Lens for Diagnosis of Dehydration.Biosensors · 2025Article
- Article
- Plasmonic smart contact lens based on etalon nanostructure for tear glucose sensing.Scientific reports · 2025Article
- Article
- Luminescence Probes in Bio-Applications: From Principle to Practice.Biosensors · 2024Review
- Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials.ACS applied bio materials · 2023Review
- Remote Measurements of Tear Electrolyte Concentrations on Both Sides of an Inserted Contact Lens.Chemosensors (Basel, Switzerland) · 2023Article
- Fluorescence Sensing Technologies for Ophthalmic Diagnosis.ACS sensors · 2022Review
- Wearable Smart Contact Lenses for Continual Glucose Monitoring: A Review.Frontiers in medicine · 2022Review
- Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?Frontiers in chemistry · 2022Review
- Fouling in ocular devices: implications for drug delivery, bioactive surface immobilization, and biomaterial design.Drug delivery and translational research · 2021Review
- Janus Hydrogel Microbeads for Glucose Sensing with pH Calibration.Sensors (Basel, Switzerland) · 2021Article
- Sodium-Sensitive Contact Lens for Diagnostics of Ocular Pathologies.Sensors and actuators. B, Chemical · 2021Article
- Fiber Optic Sensors: A Review for Glucose Measurement.Biosensors · 2021Review
- Micro/nanodevices for assessment and treatment in stomatology and ophthalmology.Microsystems & nanoengineering · 2021Review
- Non-Invasive Blood Glucose Monitoring Technology: A Review.Sensors (Basel, Switzerland) · 2020Review
- Fluorescent contact lens for continuous non-invasive measurements of sodium and chloride ion concentrations in tears.Analytical biochemistry · 2020Article
- Eyeglasses-based tear biosensing system: Non-invasive detection of alcohol, vitamins and glucose.Biosensors & bioelectronics · 2019Article
- The Progress of Glucose Monitoring-A Review of Invasive to Minimally and Non-Invasive Techniques, Devices and Sensors.Sensors (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Accurate and reliable monitoring of blood glucose is needed for the treatment of diabetes, which has many challenges, including lack of patient compliance. Measuring tear glucose is an alternative to traditional finger-stick tests used to track blood sugar levels, but glucose sensing using tears has yet to be achieved. We report a methodology for possible tear glucose monitoring using glucose-sensitive silicone hydrogel (SiHG) contact lenses, the primary type of lenses available in today's market. Initially, we assessed the interpenetrating polymer network, with nearly pure silicone and water regions, existing in the SiHGs using a polarity-sensitive probe Prodan. We then synthesized a glucose-sensitive fluorophore Quin-C18 with a hydrophobic side chain for localization of probe at the interfacial region. Using our glucose-sensing contact lens, we were able to measure varying concentrations of glucose in an in-vitro system. The Quin-C18 strongly bound to the lenses with insignificant leaching even after multiple rinses. The lenses displayed a similar response to glucose after three months of storage in water. This study demonstrates that it may be possible to develop a contact lens for continuous glucose monitoring in the near term, using our concept of fluorophore binding at the silicone-water interface.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.