ReviewCurrent urology reports2018
Infertility in the Aging Male.
Review in Current urology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research.International journal of molecular sciences · 2021Pooled it
- Influence of age on sperm characteristics evaluated by light and electron microscopies.Scientific reports · 2021Trial
- Trial
- Global burden of male infertility from 1990 to 2021 and 15 years forecast: A cross-sectional analysis of Global Burden of Disease Study 2021.Chinese medical journal · 2026Article
- Impact of aging on spermatogenic function and reproductive outcomes in repro57 heterozygous male mice: A model for age-related infertility.Journal of assisted reproduction and genetics · 2025Article
- Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian Mother, Father, and Child Cohort Study.BMC medicine · 2024Article
- Testosterone therapy for functional hypogonadism in middle-aged and elderly males: current evidence and future perspectives.Hormones (Athens, Greece) · 2024Review
- Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian Mother, Father, and Child Cohort Study.Research square · 2024Article
- Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice.iScience · 2023Article
- Altered microRNA expression profiles of human spermatozoa in normal fertile men of different ages.Asian journal of andrology · 2023Article
- The role of red ginseng in men's reproductive health: a literature review.Basic and clinical andrology · 2023Review
- Expression profiles of circular RNAs in spermatozoa from aging men.Molecular biology reports · 2023Article
- Article
- Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis.Antioxidants (Basel, Switzerland) · 2023Article
- Advanced Paternal Age Does Not Affect Medically-Relevant Obstetrical and Perinatal Outcomes following IVF or ICSI in Humans with Donated Oocytes.Journal of clinical medicine · 2023Article
- Infertility in Men: Advances towards a Comprehensive and Integrative Strategy for Precision Theranostics.Cells · 2022Review
- Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Cellular Senescence and Aging in Myotonic Dystrophy.International journal of molecular sciences · 2022Review
- Do aging, drinking, and having unhealthy weight have a synergistic impact on semen quality?Journal of assisted reproduction and genetics · 2021Article
- Incomplete proline catabolism drives premature sperm aging.Aging cell · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewIn many countries, the average age of paternity is rising. The negative effect of older age on fertility in women is well documented; however, less is known about the impact of paternal age on fecundity. In this review, we summarize the current knowledge of how paternal age affects semen parameters, reproductive success, and offspring health. RECENT
findingsContemporary evidence confirms that aged men have worse semen parameters, including overall negative changes in sperm genetics. Reproductive outcomes with unassisted pregnancy tend to be worse with older fathers. While most current studies of assisted pregnancy do show a negative effect of paternal age, there are some conflicting results. Studies continue to show an overall increased risk of health problems, particularly neuropsychiatric conditions, in the offspring of older men. While men can often maintain fertility potential throughout a lifetime, increasing evidence indicates worsening of semen parameters, including sperm genetics, and potentially worse reproductive success. Older men should also be counseled on their offspring's possible increased risk of certain medical conditions.
Indexed as
Identifiers
29774447What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.