Evidence map›Paper›PMID 29774417›Full record

ArticleEuropean journal of pediatrics2018

First report on the nationwide incidence of type 1 diabetes and ketoacidosis at onset in children in Serbia: a multicenter study.

Rade Vukovic, Maja D Jesic, Ivana Vorgucin, Sandra Stankovic, Nevena Folic, Tatjana Milenkovic, Silvija Sajic, Dragan Katanic, Sasa Zivic, Slavica Markovic and 1 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Twenty-five years of pediatric type 1 diabetes in Serbia: Trends in age at diagnosis, seasonal variation, and the proportion of diabetic ketoacidosis before, during, and after the COVID-19 pandemic.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Rade VukovicMother and Child Health Care Institute of Serbia "Dr Vukan Cupic", Radoja Dakica 8, Belgrade, 11070, Serbia. radevukovic9@gmail.com.ORCID http://orcid.org/0000-0002-1592-4105
Maja D JesicUniversity Children's Hospital, Tirsova 10, Belgrade, 11000, Serbia.
Ivana VorgucinInstitute for Children and Youth Health Care of Vojvodina, Hajduk Veljkova 10, Novi Sad, 21000, Serbia.
Sandra StankovicChildren Clinic, Clinical Center Nis, Dr Zorana Djindjica Blvd. 48a, Nis, 18000, Serbia.
Nevena FolicPediatric Clinic, Clinical Centre Kragujevac, Zmaj Jovina 30, Kragujevac, 34000, Serbia.
Tatjana MilenkovicMother and Child Health Care Institute of Serbia "Dr Vukan Cupic", Radoja Dakica 8, Belgrade, 11070, Serbia.
Silvija SajicUniversity Children's Hospital, Tirsova 10, Belgrade, 11000, Serbia.
Dragan KatanicInstitute for Children and Youth Health Care of Vojvodina, Hajduk Veljkova 10, Novi Sad, 21000, Serbia.
Sasa ZivicChildren Clinic, Clinical Center Nis, Dr Zorana Djindjica Blvd. 48a, Nis, 18000, Serbia.
Slavica MarkovicPediatric Clinic, Clinical Centre Kragujevac, Zmaj Jovina 30, Kragujevac, 34000, Serbia.
Ivan SoldatovicInstitute for Medical Statistics and Informatics, School of Medicine, University of Belgrade, Dr Subotica 15, Belgrade, 11000, Serbia.
University of Belgrade · RSInstitute of Public Health of Serbia · RSUniversity of Kragujevac · RSUniversity of Nis · RSUniversity of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data regarding incidence of type 1 diabetes (T1DM), as well as data on frequency and severity of diabetic ketoacidosis (DKA) at the time of T1DM diagnosis is of paramount importance for national and regional healthcare planning. The aim of present multicenter study was to provide the first report regarding nationwide annual incidence rates for T1DM in youth in Serbia, as well as prevalence of DKA at the time of diagnosis. Data on all pediatric patients with newly diagnosed T1DM was retrospectively collected from all 15 regional centers for pediatric diabetes in Serbia during the period 2007-2017. During the study period, average-standardized incidence of T1DM in youth < 19 years was 11.82/100,000, and 14.28/100,000 in 0-14 years age group, with an average yearly increase in incidence of 5.9%. High prevalence of DKA (35.1%) at the time of diagnosis was observed, with highest frequency in children aged < 5 years (47.2%).

conclusionThis is the first study reporting the nationwide incidence of T1DM and alarmingly high prevalence of DKA at diagnosis in youth in Serbia. The focus of public health preventive measures should be directed towards the preschoolers, considering the highest frequency and severity of DKA observed in this age group. What is Known: • Knowing regional T1DM incidence is of paramount importance for resource allocation and healthcare services provision. • DKA is the leading cause of acute mortality in youth with T1DM, and public health preventive educational measures could improve early diagnosis and reduce the frequency and severity of DKA at presentation. What is New: • Incidence of pediatric T1DM in Serbia is on the rise, with an average yearly increase of 5.9%. • Worryingly high prevalence of DKA (35.1%) at the time of T1DM diagnosis was observed, with the highest frequency of DKA in children aged < 5 years (47.2%).

Indexed as

AdolescentChildChild, PreschoolDiabetes Mellitus, Type 1Diabetic KetoacidosisFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornMalePrevalenceRetrospective StudiesRisk FactorsSerbiaChildrenDiabetic ketoacidosisIncidencePrevalenceSerbiaType 1 diabetes mellitus

Identifiers

PMID29774417
OpenAlexW2804548407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.