Evidence map›Paper›PMID 29774398›Full record

ArticleInternational journal of colorectal disease2018

Improved detection of a tumorous involvement of the mesorectal fascia and locoregional lymph nodes in locally advanced rectal cancer using DCE-MRI.

Marco Armbruster, Melvin D'Anastasi, Veronika Holzner, Martin E Kreis, Olaf Dietrich, Bernhard Brandlhuber, Anno Graser, Martina Brandlhuber

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Gender Medicine in Clinical Radiology Practice.Journal of personalized medicine · 2023
    Review
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  6. Article
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  8. Article
  9. Article
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  11. [Assessment of individualized treatment of rectal carcinoma].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Marco ArmbrusterClinic of Radiology, Ludwig Maximilians University of Munich, Marchionini Str. 15, 81377, Munich, Germany.
Melvin D'AnastasiMedical Imaging Department, Mater Dei Hospital, Tal-Qroqq, Msida, MSD 2090, Malta.
Veronika HolznerKinderkrankenhaus St.Marien Landshut, Grillparzerstraße 9, 84036, Landshut, Germany.
Martin E KreisDepartment of General-, Visceral- and Vascular Surgery, Charité University Medicine Berlin, Campus Benjamin Franklin Hindenburgdamm 30, 12200, Berlin, Germany.
Olaf DietrichClinic of Radiology, Ludwig Maximilians University of Munich, Marchionini Str. 15, 81377, Munich, Germany.
Bernhard BrandlhuberDepartment of Internal Medicine, Klinik Mühldorf am Inn, Krankenhausstraße 1, 84453, Mühldorf am Inn, Germany.
Anno GraserGemeinschaftspraxis Radiologie München, Burgstraße 7, 80331, Munich, Germany.
Martina BrandlhuberClinic of Radiology, Ludwig Maximilians University of Munich, Marchionini Str. 15, 81377, Munich, Germany. Martina.Brandlhuber@med.uni-muenchen.de.ORCID http://orcid.org/0000-0001-8332-3726
Ludwig-Maximilians-Universität München · DECharité - Universitätsmedizin Berlin · DEIhre-Radiologen · DEMater Dei Hospital · MTUniversity of Applied Sciences Landshut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe prediction of an infiltration of the mesorectal fascia (MRF) and malignant lymph nodes is essential for treatment planning and prognosis of patients with rectal cancer. The aim of this study was to assess the additional diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the detection of a malignant involvement of the MRF and of mesorectal lymph nodes in patients with locally advanced rectal cancer.

methodsIn this prospective study, 22 patients with locally advanced rectal cancer were examined with 1.5-T MRI between September 2012 and April 2015. Histopathological assessment of tumor size, tumor infiltration to the MRF, and malignant involvement of locoregional lymph nodes served as standard of reference. Sensitivity and specificity of detecting MRF infiltration and malignant nodes (nodal cut-off size [NCO] ≥ 5 and ≥ 10 mm, respectively) was determined by conventional MRI (cMRI; precontrast and postcontrast T1-weighted, T2-weighted, and diffusion-weighted images) and by additional semi-quantitative DCE-MRI maps (cMRI+DCE-MRI).

resultsCompared to cMRI, additional semi-quantitative DCE-MRI maps significantly increased sensitivity (86 vs. 71% [NCO ≥ 5 mm]/29% [NCO ≥ 10 mm]) and specificity (90 vs. 70% [NCO ≥ 5 mm]) of detecting malignant lymph nodes (p < 0.05). Moreover, DCE-MRI significantly augmented specificity (91 vs. 82%) of discovering a MRF infiltration (p < 0.05), while there was no change in sensitivity (83%; p > 0.05).

conclusionDCE-MRI considerably increases both sensitivity and specificity for the detection of small mesorectal lymph node metastases (≥ 5 mm but < 10 mm) and sufficiently improves specificity of a suspected MRF infiltration in patients with locally advanced rectal cancer.

Indexed as

Magnetic Resonance ImagingAdultAgedAged, 80 and overFasciaFemaleHumansLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm StagingProspective StudiesRectal NeoplasmsSensitivity and SpecificityDCE-MRILymph nodesMesorectal fasciaPerfusion parametersRectal cancer

Identifiers

PMID29774398
OpenAlexW2804088528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.