ReviewPediatric cardiology2018
Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing.
Review in Pediatric cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Electrophysiological phenotyping of left ventricular noncompaction cardiomyopathy in pediatric populations: A systematic review.Physiological reports · 2024Pooled it
- LMNA Deficiency Reveals a Role for SK3 Channel Dysfunction in Atrioventricular Block.JACC. Clinical electrophysiology · 2026Article
- The Hidden Regulators: MicroRNAs in Pediatric Heart Development and Disease.Journal of clinical medicine · 2025Review
- The impact of common and rare genetic variants on bradyarrhythmia development.Nature genetics · 2025Article
- How Advanced are Conductive Nanocomposite Hydrogels for Repairing and Monitoring Myocardial Infarction?International journal of nanomedicine · 2025Review
- Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes Towards a Purkinje Fiber Fate.bioRxiv : the preprint server for biology · 2024Article
- Development of the Cardiac Conduction System.Advances in experimental medicine and biology · 2024Article
- DbhNature communications · 2023Article
- The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation.Development (Cambridge, England) · 2023Article
- Single-cell RNA sequencing of murine hearts for studying the development of the cardiac conduction system.Scientific data · 2023Article
- Article
- Recent Advances in Designing Electroconductive Biomaterials for Cardiac Tissue Engineering.Advanced healthcare materials · 2022Review
- Application of Three-Dimensional Culture Method in the Cardiac Conduction System Research.Methods and protocols · 2022Article
- GOing Forward With the Cardiac Conduction System Using Gene Ontology.Frontiers in genetics · 2022Article
- New Insights into the Development and Morphogenesis of the Cardiac Purkinje Fiber Network: Linking Architecture and Function.Journal of cardiovascular development and disease · 2021Review
- The margin of internal risk volume on atrial septal and ventricular septal based on electrocardiograph gating 4DCT.Annals of translational medicine · 2021Article
- The heart of the neural crest: cardiac neural crest cells in development and regeneration.Development (Cambridge, England) · 2020Review
- NOTCH1 is critical for fibroblast-mediated induction of cardiomyocyte specialization into ventricular conduction system-like cells in vitro.Scientific reports · 2020Article
- The expanding phenotypes of cohesinopathies: one ring to rule them all!Cell cycle (Georgetown, Tex.) · 2019Review
- Learn from Your Elders: Developmental Biology Lessons to Guide Maturation of Stem Cell-Derived Cardiomyocytes.Pediatric cardiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The components of the cardiac conduction system (CCS) generate and propagate the electrical impulse that initiates cardiac contraction. These interconnected components share properties, such as automaticity, that set them apart from the working myocardium of the atria and ventricles. A variety of tools and approaches have been used to define the CCS lineages. These include genetic labeling of cells expressing lineage markers and fate mapping of dye labeled cells, which we will discuss in this review. We conclude that there is not a single CCS lineage, but instead early cell fate decisions segregate the lineages of the CCS components while they remain interconnected. The latter is relevant for development of therapies for conduction system disease that focus on reprogramming cardiomyocytes or instruction of pluripotent stem cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.