Evidence map›Paper›PMID 29774234›Full record

ArticleScience advances2018

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.

Samah Matmati, Mélina Vaurs, José M Escandell, Laetitia Maestroni, Toru M Nakamura, Miguel G Ferreira, Vincent Géli, Stéphane Coulon

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Telomere Replication: Solving Multiple End Replication Problems.Frontiers in cell and developmental biology · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Tpz1Communications biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Samah MatmatiCRCM, CNRS, INSERM, Aix-Marseille Université, Institut Paoli-Calmettes, Equipe Labellisée Ligue, 27 Boulevard Lei Roure, Marseille, France.
Mélina VaursCRCM, CNRS, INSERM, Aix-Marseille Université, Institut Paoli-Calmettes, Equipe Labellisée Ligue, 27 Boulevard Lei Roure, Marseille, France.
José M EscandellTelomere and Genome Stability Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Laetitia MaestroniCRCM, CNRS, INSERM, Aix-Marseille Université, Institut Paoli-Calmettes, Equipe Labellisée Ligue, 27 Boulevard Lei Roure, Marseille, France.
Toru M NakamuraDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-5752-0814
Miguel G FerreiraTelomere and Genome Stability Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal.ORCID 0000-0002-8363-7183
Vincent GéliCRCM, CNRS, INSERM, Aix-Marseille Université, Institut Paoli-Calmettes, Equipe Labellisée Ligue, 27 Boulevard Lei Roure, Marseille, France.
Stéphane CoulonCRCM, CNRS, INSERM, Aix-Marseille Université, Institut Paoli-Calmettes, Equipe Labellisée Ligue, 27 Boulevard Lei Roure, Marseille, France.ORCID 0000-0001-8090-914X
Centre National de la Recherche Scientifique · FRInstituto Gulbenkian de Ciência · PTUniversity of Illinois Chicago · US

Funding

Roles of Checkpoint and DNA Repair Proteins in Fission Yeast Telomere MaintenanceR01GM078253 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NAKAMURA, TORU · 2006 to 2019
$4.1M
NIGMS NIH HHS R01 GM078253
6 · The paper itself

Abstract

Mammalian CST (CTC1-STN1-TEN1) complex fulfills numerous functions including rescue of the stalled replication forks and termination of telomerase action. In fission yeast lacking the CTC1 ortholog, the Stn1-Ten1 complex restricts telomerase action via its sumoylation-mediated interaction with Tpz1

Indexed as

Protein Interaction Domains and MotifsDNA ReplicationDNA, Single-StrandedGene ExpressionModels, BiologicalMolecular ChaperonesMutationProtein BindingSchizosaccharomycesSchizosaccharomyces pombe ProteinsSUMO-1 ProteinTelomeraseTelomereTelomere-Binding ProteinsDNA, Single-StrandedMolecular ChaperonesSchizosaccharomyces pombe ProteinsSti1 protein, S pombeSUMO-1 ProteinTelomeraseTelomere-Binding ProteinsTen1 protein, S pombe

Identifiers

PMID29774234
PMCPMC5955624
OpenAlexW2804483413

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.