Evidence map›Paper›PMID 29774210›Full record

ReviewFrontiers in public health2018

Hypertension in Children: Role of Obesity, Simple Carbohydrates, and Uric Acid.

Antonina Orlando, Emanuela Cazzaniga, Marco Giussani, Paola Palestini, Simonetta Genovesi

Abstract readReview
In one paragraph

Review in Frontiers in public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. A prospective analysis to assess the multifactorial risk of childhood-onset hypertension: the ExAMIN Youth SA study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Observational
  4. Article
  5. Review
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  9. Review
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  19. Article
  20. Association of Ang-(1-7) and des-ArgHypertension research : official journal of the Japanese Society of Hypertension · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Antonina OrlandoDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Emanuela CazzanigaDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Marco GiussaniFamily Pediatrician, Azienda Sanitaria Locale della Provincia di Milano, Milan, Italy.
Paola PalestiniDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Simonetta GenovesiDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past 60 years there has been a dramatic increase in the prevalence of overweight in children and adolescents, ranging from 4% in 1975 to 18% in 2016. Recent estimates indicate that overweight or obese children and adolescents are more than 340 million. Obesity is often associated with hypertension, which is an important cardiovascular risk factor. Recent studies show that the presence of hypertension is a frequent finding in the pediatric age. Hypertensive children easily become hypertensive adults. This phenomenon contributes to increasing cardiovascular risk in adulthood. Primary hypertension is a growing problem especially in children and adolescents of western countries, largely because of its association with the ongoing obesity epidemic. Recently, it has been hypothesized that a dietary link between obesity and elevated blood pressure (BP) values could be simple carbohydrate consumption, particularly fructose, both in adults and in children. Excessive intake of fructose leads to increased serum uric acid (SUA) and high SUA values are independently associated with the presence of hypertension and weaken the efficacy of lifestyle modifications in children. The present review intends to provide an update of existing data regarding the relationship between BP, simple carbohydrates (particularly fructose), and uric acid in pediatric age. In addition, we analyze the national policies that have been carried out over the last few years, in order to identify the best practices to limit the socio-economic impact of the effects of excessive sugar consumption in children.

Indexed as

cardiovascular diseasefructosehypertensionobesityuric acid

Identifiers

PMID29774210
PMCPMC5943632

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.