ArticleQuantitative imaging in medicine and surgery2018
Protein-modified ultra-small gold clusters for dual-modal
Article in Quantitative imaging in medicine and surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Advances of gold nanoclusters for bioimaging.iScience · 2022Review
- Quantitative multilayered assessment of skin lightening by photoacoustic microscopy.Quantitative imaging in medicine and surgery · 2022Article
- Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria.Sensors (Basel, Switzerland) · 2019Article
- Functional probes for cardiovascular molecular imaging.Quantitative imaging in medicine and surgery · 2018Review
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Authors and funding
4 authors.
Funding
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Abstract
backgroundConstruction of nanoprobes for dual-modal fluorescence/photoacoustic imaging (PAI) is of great importance for the detection of disease pathology and the development of innovative therapeutics. Previously ultra-small gold clusters were designed and used as contrast agents for fluorescence imaging (FLI). However, it is not clear whether they can also serve as promising probes for PAI. In this study, protein-modified ultra-small gold clusters are produced and examined quantitatively as enhanced contrast agents for dual-modal
methodsTo construct the dual-modal ultra-small gold clusters, HAuCl
resultsThe gold nanoclusters were synthesized with diameters of about 3 nm, which showed the broad absorption with a characteristic peak centered at 520 nm. A strong near-infrared emission ranging from 600 to 750 nm was also observed for the gold clusters. In addition, the cell viability was more than 90% even at a high concentration of the nanoprobes. The zebrafish cultivated with the gold clusters exhibited dramatically enhanced fluorescence and photoacoustic signal intensities.
conclusionsQuantitative analysis results demonstrated that BSA-modified gold clusters were excellent contrast agents for
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