ReviewCurrent transplantation reports2018
Pushing the Limits: Machine Preservation of the Liver as a Tool to Recondition High-Risk Grafts.
Review in Current transplantation reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Biliary Viability Assessment and Treatment Options of Biliary Injury During Normothermic Liver Perfusion-A Systematic Review.Transplant international : official journal of the European Society for Organ Transplantation · 2022Pooled it
- Review
- Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Potential in Organ Transplantation.Stem cells international · 2024Review
- Viability Assessment in Liver Transplantation-What Is the Impact of Dynamic Organ Preservation?Biomedicines · 2021Review
- Article
- The Role of Metabolomics in Current Concepts of Organ Preservation.International journal of molecular sciences · 2020Review
- Preventing Tumour Recurrence after Liver Transplantation: The Role of Machine Perfusion.International journal of molecular sciences · 2020Review
- Non-ischemic Heart Preservation via Hypothermic Cardioplegic Perfusion Induces Immunodepletion of Donor Hearts Resulting in Diminished Graft Infiltration Following Transplantation.Frontiers in immunology · 2020Article
- Machine perfusion strategies in liver transplantation.Hepatobiliary surgery and nutrition · 2019Review
- Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies.Journal of biomedical research · 2019Article
- Bioengineering approaches to organ preservation ex vivo.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Phenothiazines Enhance the Hypothermic Preservation of Liver Grafts: A Pilot in Vitro Study.Cell transplantation · 2019Article
- Machine perfusion of the liver: Which is the best technique to mitigate ischaemia-reperfusion injury?World journal of transplantation · 2019Review
- Article
- Article
- Impact of machine perfusion of the liver on post-transplant biliary complications: A systematic review.World journal of transplantation · 2018Article
- The impact of major extended donor criteria on graft failure and patient mortality after liver transplantation.Langenbeck's archives of surgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of the reviewMachine perfusion (MP) is a novel technology recently introduced in liver transplantation, redefining the current practice of organ preservation and pushing the limits of high-risk liver utilisation. This review highlights the key benefits of machine perfusion over conventional static cold storage (SCS), demonstrated in human liver research and clinical transplants. RECENT
findingsThe first clinical trials have demonstrated both safety and feasibility of MP. The most recent transplant series and result from a randomised trial suggest the technology is superior to SCS. The key benefits include extended period of organ preservation, decreased incidence of early allograft dysfunction and reduction of biliary complications. Normothermic liver perfusion allows viability testing to guide transplantability of the highest-risk organs. This technology also provides opportunities for therapeutic interventions to improve liver function and quality in organs that are currently declined for clinical use. SUMMARY: Machine perfusion is likely to transform the liver preservation pathway and to improve utilisation of high-risk grafts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.