ArticleFrontiers in immunology2018
Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to
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In one paragraph
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Meta-analysis reveals a core iron-responsive gene signature in Mycobacterium tuberculosis linking siderophore biosynthesis, virulence, and metabolic adaptation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Pooled it
- Targeting macrophage ferritin heavy chain mitigates ferroptosis and lung injury in experimental acute respiratory distress syndrome.Nature communications · 2026Article
- Macrophage ferritin heavy chain/α-synuclein regulatory axis modulates ferroptosis during kidney injury.JCI insight · 2026Article
- Macrophage Response to Avirulent and Virulent Mycobacterium tuberculosis and Anti-TB Effects of Exosome Treatment.Genomics, proteomics & bioinformatics · 2025Article
- Dysregulation of the JNK signaling pathway in tuberculosis: mechanisms and therapeutic strategies.Frontiers in cellular and infection microbiology · 2025Review
- Mycobacterium tuberculosis modulates NUDT21-mediated alternative polyadenylation to enhance FTH1 expression in macrophages and promotes intracellular growth.Frontiers in cellular and infection microbiology · 2025Article
- Myeloid-specific ferritin light chain deletion does not exacerbate sepsis-associated AKI.American journal of physiology. Renal physiology · 2024Article
- Mechanisms controlling cellular and systemic iron homeostasis.Nature reviews. Molecular cell biology · 2024Review
- Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis.Frontiers in immunology · 2024Article
- BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.Nature microbiology · 2024Article
- Heme catabolism and heme oxygenase-1-expressing myeloid cells in pathophysiology.Frontiers in immunology · 2024Review
- NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis.Nature communications · 2023Article
- Serum iron levels in tuberculosis patients and household contacts and its association with natural resistance-associated macrophage protein 1 polymorphism and expression.The clinical respiratory journal · 2023Article
- Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth.The Journal of clinical investigation · 2023Article
- Review
- Disease tolerance: a protective mechanism of lung infections.Frontiers in cellular and infection microbiology · 2023Review
- Selection of Ideal Reference Genes for Gene Expression Analysis in COVID-19 and Mucormycosis.Microbiology spectrum · 2022Article
- A high-resolution 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions.EMBO molecular medicine · 2022Article
- GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection.The Journal of experimental medicine · 2022Article
- Targeting ferroptosis as a vulnerability in pulmonary diseases.Cell death & disease · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 4 countries.
Vineel P ReddyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Krishna C ChintaDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Vikram SainiDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Joel N GlasgowDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Travis D HullDivision of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, AL, United States.
Amie TraylorNephrology Research and Training Center, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL, United States.
Fernanda Rey-StolleCentro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Madrid, Spain.
Miguel P SoaresInstituto Gulbenkian de Ciência, Oeiras, Portugal.
Rajhmun MadanseinInkosi Albert Luthuli Central Hospital, University of KwaZulu-Natal, Durban, South Africa.
Md Aejazur RahmanAfrica Health Research Institute (AHRI), Durban, South Africa.
Coral BarbasCentro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Madrid, Spain.
Kievershen NarganDepartment of Anatomical Pathology, National Health Laboratory Service, University of KwaZulu-Natal, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
Threnesan NaidooDepartment of Anatomical Pathology, National Health Laboratory Service, University of KwaZulu-Natal, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
Pratistadevi K RamdialDepartment of Anatomical Pathology, National Health Laboratory Service, University of KwaZulu-Natal, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
James F GeorgeDivision of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, AL, United States.
Anupam AgarwalNephrology Research and Training Center, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL, United States.
Adrie J C SteynDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USUniversity of KwaZulu-Natal · ZAAfrica Health Research Institute · ZAUniversidad San Pablo CEU · ESBirmingham VA Medical Center · USInstituto Gulbenkian de Ciência · PTNational Health Laboratory Service · ZA
Funding
UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3MHuman Heme Oxygenase-1 Gene Regulation in Renal InjuryR01DK059600 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ANUPAM, GEORGE, JAMES F · 2002 to 2019
$4.5MHeme oxygenase-1 and the bioenergetic threshold of latent TB and HIV co-infectionR01AI111940 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2015 to 2019
$2.0MImmunometabolism of M. tuberculosis/HIV co-infectionR21AI127182 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2016 to 2017
$349kEuropean Research Council 294709NIAID NIH HHS R01 AI111940NIAID NIH HHS R21 AI127182NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK059600
Abstract
Iron is an essential factor for the growth and virulence of
Indexed as
AnimalsApoferritinsCase-Control StudiesDisease Models, AnimalDisease SusceptibilityEnergy MetabolismFemaleFerritinsHealthy VolunteersHepcidinsHumansIronLungMaleMiceMice, Inbred C57BLApoferritinsFerritinsFth1 protein, mouseHepcidinsIronOxidoreductasesbioenergeticsenergy metabolismferritin H chainimmunometabolismirontuberculosis
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.