Evidence map›Paper›PMID 29774009›Full record

ReviewFrontiers in neurology2018

Signaling Pathways and Cellular Mechanisms Regulating Mossy Fiber Sprouting in the Development of Epilepsy.

Christin M Godale, Steve C Danzer

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Cell-Intrinsic Regulation of Epilepsy-Associated Pathology by mTORC1 and mTORC2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Article
  6. Zinc Water Prevents Autism-Like Behaviors in the BTBR Mice.Biological trace element research · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Frontiers in neuroscience · 2022
    Article
  14. Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christin M GodaleDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Steve C DanzerDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Cincinnati Children's Hospital Medical Center · US

Funding

Selective disruption of hippocampal dentate granule cells in autism: impact of PTR01NS065020 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2009 to 2023
$6.1M
mTOR regulation of aberrant neuronal integration and epileptogenesis in epilepsyR01NS062806 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2009 to 2019
$3.6M
NINDS NIH HHS R01 NS062806NINDS NIH HHS R01 NS065020
6 · The paper itself

Abstract

The sprouting of hippocampal dentate granule cell axons, termed mossy fibers, into the dentate inner molecular layer is one of the most consistent findings in tissue from patients with mesial temporal lobe epilepsy. Decades of research in animal models have revealed that mossy fiber sprouting creates

Indexed as

adult neurogenesisdentate granule cellepileptogenesismTORphosphatase and tensin homolog/PI3K/Akt

Identifiers

PMID29774009
PMCPMC5943493
OpenAlexW2802355680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.