ArticleMolecular breeding : new strategies in plant improvement2018
Discovery and validation of genomic regions associated with resistance to maize lethal necrosis in four biparental populations.
Article in Molecular breeding : new strategies in plant improvement, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Introgression of QTL hotspot regions enhances grain yield and maize lethal necrosis resistance in elite maize lines.Scientific reports · 2026Article
- Targeted knockout of a host peroxisomal peptidase confers field resistance to maize lethal necrosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Global Transcriptomic Analysis of Inbred Lines Reveal Candidate Genes for Response to Maize Lethal Necrosis.Plants (Basel, Switzerland) · 2025Article
- A combination of joint linkage and genome-wide association study reveals putative candidate genes associated with resistance to northern corn leaf blight in tropical maize.Frontiers in plant science · 2024Article
- Linkage mapping and genomic prediction of grain quality traits in tropical maize (Frontiers in genetics · 2024Article
- Inheritance of resistance to maize lethal necrosis in tropical maize inbred lines.Frontiers in plant science · 2024Article
- Genome-wide association studies reveal novel loci for resistance to groundnut rosette disease in the African core groundnut collection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Review
- Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa.BMC plant biology · 2022Review
- Article
- Article
- Genetic diversity and selective sweeps in historical and modern Canadian spring wheat cultivars using the 90K SNP array.Scientific reports · 2021Article
- Breeding maize (Plant breeding = Zeitschrift fur Pflanzenzuchtung · 2021Review
- Discovery and Validation of a Recessively Inherited Major-Effect QTL Conferring Resistance to Maize Lethal Necrosis (MLN) Disease.Frontiers in genetics · 2021Article
- Introgression of Maize Lethal Necrosis Resistance Quantitative Trait Loci Into Susceptible Maize Populations and Validation of the Resistance Under Field Conditions in Naivasha, Kenya.Frontiers in plant science · 2021Article
- The RNA of Maize Chlorotic Mottle Virus, an Obligatory Component of Maize Lethal Necrosis Disease, Is Translated via a Variant Panicum Mosaic Virus-Like Cap-Independent Translation Element.Journal of virology · 2020Article
- Maize lethal necrosis (MLN): Efforts toward containing the spread and impact of a devastating transboundary disease in sub-Saharan Africa.Virus research · 2020Review
- Hybrid Breeding for MLN Resistance: Heterosis, Combining Ability, and Hybrid Prediction.Plants (Basel, Switzerland) · 2020Article
- Genetic Dissection of Resistance to Gray Leaf Spot by Combining Genome-Wide Association, Linkage Mapping, and Genomic Prediction in Tropical Maize Germplasm.Frontiers in plant science · 2020Article
- Genetic Analysis of QTL for Resistance to Maize Lethal Necrosis in Multiple Mapping Populations.Genes · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In sub-Saharan Africa, maize is the key determinant of food security for smallholder farmers. The sudden outbreak of maize lethal necrosis (MLN) disease is seriously threatening the maize production in the region. Understanding the genetic basis of MLN resistance is crucial. In this study, we used four biparental populations applied linkage mapping and joint linkage mapping approaches to identify and validate the MLN resistance-associated genomic regions. All populations were genotyped with low to high density markers and phenotyped in multiple environments against MLN under artificial inoculation. Phenotypic variation for MLN resistance was significant and heritability was moderate to high in all four populations for both early and late stages of disease infection. Linkage mapping revealed three major quantitative trait loci (QTL) on chromosomes 3, 6, and 9 that were consistently detected in at least two of the four populations. Phenotypic variance explained by a single QTL in each population ranged from 3.9% in population 1 to 43.8% in population 2. Joint linkage association mapping across three populations with three biometric models together revealed 16 and 10 main effect QTL for MLN-early and MLN-late, respectively. The QTL identified on chromosomes 3, 5, 6, and 9 were consistent with the QTL identified by linkage mapping. Ridge regression best linear unbiased prediction with five-fold cross-validation revealed high accuracy for prediction across populations for both MLN-early and MLN-late. Overall, the study discovered and validated the presence of major effect QTL on chromosomes 3, 6, and 9 which can be potential candidates for marker-assisted breeding to improve the MLN resistance.
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