ArticleNature protocols2018
An approach to monitoring home-cage behavior in mice that facilitates data sharing.
Article in Nature protocols, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Traumatic life experiences during critical periods lead to diverse developmental trajectories.Cell reports. Medicine · 2026Article
- Article
- Rodent tests of depression and anxiety: Construct validity and translational relevance.Cognitive, affective & behavioral neuroscience · 2024Review
- Data repurposing from digital home cage monitoring enlightens new perspectives on mouse motor behaviour and reduction principle.Scientific reports · 2023Article
- Galactic Cosmic Irradiation Alters Acute and Delayed Species-Typical Behavior in Male and Female Mice.Life (Basel, Switzerland) · 2023Article
- PiE: an open-source pipeline for home cage behavioral analysis.Frontiers in neuroscience · 2023Article
- Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington's disease.Frontiers in behavioral neuroscience · 2023Article
- Blueprints for measuring natural behavior.iScience · 2022Review
- A hierarchical 3D-motion learning framework for animal spontaneous behavior mapping.Nature communications · 2021Article
- An open-source device for measuring food intake and operant behavior in rodent home-cages.eLife · 2021Article
- Article
- Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption.CNS neuroscience & therapeutics · 2020Article
- Three Pillars of Automated Home-Cage Phenotyping of Mice: Novel Findings, Refinement, and Reproducibility Based on Literature and Experience.Frontiers in behavioral neuroscience · 2020Review
- The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents.Frontiers in neuroscience · 2020Review
- Selective Knockout of theFrontiers in behavioral neuroscience · 2020Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetically modified mice are used as models for a variety of human behavioral conditions. However, behavioral phenotyping can be a major bottleneck in mouse genetics because many of the classic protocols are too long and/or are vulnerable to unaccountable sources of variance, leading to inconsistent results between centers. We developed a home-cage approach using a Chora feeder that is controlled by-and sends data to-software. In this approach, mice are tested in the standard cages in which they are held for husbandry, which removes confounding variables such as the stress induced by out-of-cage testing. This system increases the throughput of data gathering from individual animals and facilitates data mining by offering new opportunities for multimodal data comparisons. In this protocol, we use a simple work-for-food testing strategy as an example application, but the approach can be adapted for other experiments looking at, e.g., attention, decision-making or memory. The spontaneous behavioral activity of mice in performing the behavioral task can be monitored 24 h a day for several days, providing an integrated assessment of the circadian profiles of different behaviors. We developed a Python-based open-source analytical platform (Phenopy) that is accessible to scientists with no programming background and can be used to design and control such experiments, as well as to collect and share data. This approach is suitable for large-scale studies involving multiple laboratories.
Indexed as
Identifiers
29773907What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.