ArticleScientific reports2018
Association between urinary sodium excretion and uric acid, and its interaction on the risk of prehypertension among Chinese young adults.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Dietary Sodium Intake and Health Indicators: A Systematic Review of Published Literature between January 2015 and December 2019.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- SGLT2 Inhibition and Uric Acid Excretion in Patients with Type 2 Diabetes and Normal Kidney Function.Clinical journal of the American Society of Nephrology : CJASN · 2022Trial
- Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study.Disease markers · 2020Trial
- Article
- LincRNA-p21/AIF-1/CMPK2/NLRP3 pathway promoted inflammation, autophagy and apoptosis of human tubular epithelial cell induced by urate via exosomes.Scientific reports · 2024Article
- Adherence to Mediterranean Diet, Dietary Salt Intake, and Susceptibility to Nephrolithiasis: A Case-Control Study.Nutrients · 2024Article
- Sex differences in impact of cumulative systolic blood pressure from childhood to adulthood on albuminuria in midlife: a 30-year prospective cohort study.BMC public health · 2023Article
- The association of urinary prostaglandins with uric acid in hyperuricemia patients.BMC nephrology · 2022Article
- Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study.EClinicalMedicine · 2022Article
- Baseline and change in serum uric acid predict the progression from prehypertension to hypertension: a prospective cohort study.Journal of human hypertension · 2022Article
- Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio has a non-linear association with non-alcoholic fatty liver disease: A secondary prospective cohort study in non-obese Chinese adults.Frontiers in medicine · 2022Article
- Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults.Frontiers in cardiovascular medicine · 2022Article
- Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Pre-Hypertension and Its Determinants in Healthy Young Adults: Analysis of Data from the Korean National Health and Nutrition Examination Survey VII.International journal of environmental research and public health · 2021Article
- Risk factors for electrocardiographic left ventricular hypertrophy in a young Chinese general population: the Hanzhong adolescent cohort study.BMC cardiovascular disorders · 2021Article
- Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study.European journal of clinical nutrition · 2021Article
- Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults.Frontiers in cardiovascular medicine · 2021Article
- The effect of uric acid and urinary sodium excretion on prehypertension: a nationwide population-based study.BMC cardiovascular disorders · 2020Article
- Predictors for progressions of brachial-ankle pulse wave velocity and carotid intima-media thickness over a 12-year follow-up: Hanzhong Adolescent Hypertension Study.Journal of hypertension · 2019Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High uric acid (UA) level and high salt intake are reportedly associated with cardiovascular disease. This study investigated the association between UA and urinary sodium excretion, as well as its interaction on the risk of prehypertension. A total of 1869 participants without hypertension were recruited from a previously established cohort in Shaanxi Province, China. The participants were classified as normotensive or prehypertensive on the basis of their blood pressure. Increasing quartiles of sodium excretion were associated with high urinary UA/creatinine levels in prehypertensive participants. Estimated sodium excretion positively correlated with urinary UA/creatinine excretions in the prehypertensive group. In addition, the multivariate-adjusted odds ratios for prehypertension compared with normotension were 1.68 (1.27-2.22) for sodium excretion and 1.71 (1.21-2.42) for serum UA. Increasing sodium excretion and serum UA were associated with higher risk of prehypertension. Compared with the lowest quartiles, the highest sodium excretion and serum UA quartiles entailed 3.48 times greater risk of prehypertension. Sodium excretion is associated with urinary UA excretion in prehypertensive participants. The present study shows that high levels of salt intake and serum UA simultaneously are associated with a higher risk of prehypertension.
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