ArticleNature communications2018
Elucidating the genetic architecture of reproductive ageing in the Japanese population.
Open access · goldAbstract readComparative Study
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 6 pooled it
9.2field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Multi-ancestry genome-wide association analyses of polycystic ovary syndrome.Nature genetics · 2025Pooled it
- The genetic architecture of age at menarche and its causal effects on other traits.Journal of human genetics · 2024Pooled it
- Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.Human reproduction (Oxford, England) · 2024Pooled it
- Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.Journal of human genetics · 2023Pooled it
- Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche.Human reproduction (Oxford, England) · 2021Pooled it
- Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study.Cancer medicine · 2019Pooled it
- NEMP1 organizes the meiotic telomere-LINC interface to control chromosome movement and telomere integrity.bioRxiv : the preprint server for biology · 2026Article
- Effects of testosterone on gene expression in males and females across 40 human tissues.Scientific reports · 2026Article
- Clinical and genetic evidence from East Asian cohorts linking family history burden and menarche timing to curve severity in adolescent idiopathic scoliosis.Frontiers in endocrinology · 2026Article
- Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.Journal of Korean biological nursing science · 2025Article
- Dual-route embedding-aware graph neural networks for drug repositioning.Briefings in bioinformatics · 2025Article
- Identification of loci associated with women's reproductive traits and exploration of a shared genetic basis with obesity.Human genomics · 2025Article
- The age at natural menopause of Chinese Han and Tibetan women.Frontiers in endocrinology · 2025Article
- Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction and infertility.Theranostics · 2025Article
- Article
- Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations.Nature communications · 2024Article
- Understanding the genetic complexity of puberty timing across the allele frequency spectrum.Nature genetics · 2024Article
- Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- Interaction between cigarette smoking and genetic polymorphisms on the associations with age of natural menopause and reproductive lifespan: the Singapore Chinese Health Study.Human reproduction (Oxford, England) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Momoko HorikoshiLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, 230-0045, Japan. momoko.horikoshi@riken.jp.
Felix R DayMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-3789-7651
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Makoto HirataLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Koichi MatsudaLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Kazuyoshi IshigakiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Masahiro KanaiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Hollis WrightPrimate Genetics Section/Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, 97006, USA.
Carlos A ToroPrimate Genetics Section/Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, 97006, USA.ORCID http://orcid.org/0000-0002-7355-7534
Sergio R OjedaDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, 97006, USA.
Alejandro LomnicziPrimate Genetics Section/Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, 97006, USA.ORCID http://orcid.org/0000-0003-4535-0103
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
John R B PerryMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK. john.perry@mrc-epid.cam.ac.uk.
Oregon National Primate Research Center · USRIKEN Center for Integrative Medical Sciences · JPUniversity of Cambridge · GBThe University of Tokyo · JPHarvard University · USKyoto University · JP
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MMULTIDISCIPLINARY TRAINING IN NEUROENDOCRINOLOGYT32DK007680 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOODMAN, RICHARD H. · 1991 to 2015
$6.8MMetabolic Control of Puberty: Epigenetic LinksR01HD084542 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI LOMNICZI, ALEJANDRO · 2015 to 2019
$2.6MREPRODUCTIVE BIOLOGY--MULTIDISCIPLINARYT32HD007133 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROSELLI, CHARLES E. · 1985 to 2014
$2.2MMetabolic Control of Puberty via EpigeneticsF32HD086904 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI TORO, CARLOS ALEJANDRO · 2016 to 2018
$99kMedical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_12015/2NICHD NIH HHS F32 HD086904NICHD NIH HHS R01 HD084542NICHD NIH HHS T32 HD007133NIDDK NIH HHS T32 DK007680NIH HHS P51 OD011092
Abstract
Population studies elucidating the genetic architecture of reproductive ageing have been largely limited to European ancestries, restricting the generalizability of the findings and overlooking possible key genes poorly captured by common European genetic variation. Here, we report 26 loci (all P < 5 × 10
Indexed as
AdolescentAdultAge FactorsAgingAnimalsAsian PeopleChildFemaleGene Expression Regulation, DevelopmentalGene FrequencyGenetic LociGenetic VariationHumansHypothalamusJapanMacaca mulatta
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.