ArticleMolecular systems biology2018
The relative resistance of children to sepsis mortality: from pathways to drug candidates.
Article in Molecular systems biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease.Molecular neurodegeneration · 2025Article
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- PanomiR: a systems biology framework for analysis of multi-pathway targeting by miRNAs.Briefings in bioinformatics · 2023Article
- Treating COVID-19: Targeting the Host Response, Not the Virus.Life (Basel, Switzerland) · 2023Review
- Gene Co-Expression Analysis Identified Preserved and Survival-Related Modules in Severe Blunt Trauma, Burns, Sepsis, and Systemic Inflammatory Response Syndrome.International journal of general medicine · 2021Article
- Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children.Scientific data · 2020Article
- Evolutionary medical insights into the SARS-CoV-2 pandemic.Evolution, medicine, and public health · 2020Article
- Inaccuracy of the log-rank approximation in cancer data analysis.Molecular systems biology · 2019Article
- Learning lessons in sepsis from the children.Molecular systems biology · 2018Article
- The relative resistance of children to sepsis mortality: from pathways to drug candidates.Molecular systems biology · 2018Article
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6 authors.
Funding
Abstract
Attempts to develop drugs that address sepsis based on leads developed in animal models have failed. We sought to identify leads based on human data by exploiting a natural experiment: the relative resistance of children to mortality from severe infections and sepsis. Using public datasets, we identified key differences in pathway activity (Pathprint) in blood transcriptome profiles of septic adults and children. To find drugs that could promote beneficial (child) pathways or inhibit harmful (adult) ones, we built an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.