Evidence map›Paper›PMID 29773664›Full record

Observational studyPediatrics2018

Cognitive Development and Quality of Life Associated With BPD in 10-Year-Olds Born Preterm.

Sudhir Sriram, Michael D Schreiber, Michael E Msall, Karl C K Kuban, Robert M Joseph, T Michael O' Shea, Elizabeth N Allred, Alan Leviton, ELGAN Study Investigators

Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Systemic steroids and bronchopulmonary dysplasia: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
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  13. [Prognosis of bronchopulmonary dysplasia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
  14. Childhood outcomes following discharge from a referral bronchopulmonary dysplasia program.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  15. Article
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  17. Extracellular Vesicle ASC: A Novel Mediator for Lung-Brain Axis in Preterm Brain Injury.American journal of respiratory cell and molecular biology · 2024
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Sudhir SriramDepartment of Pediatrics, Section of Neonatology, and ssriram@peds.bsd.uchicago.edu.
Michael D SchreiberDepartment of Pediatrics, Section of Neonatology, and.
Michael E MsallSection of Developmental and Behavioral Pediatrics, Kennedy Research Center on Intellectual and Developmental Disabilities, The University of Chicago, Chicago, Illinois.
Karl C K KubanDivision of Pediatric Neurology, Departments of Pediatrics and.
Robert M JosephAnatomy and Neurobiology, School of Medicine, Boston University, Boston, Massachusetts.
T Michael O' SheaDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and.
Elizabeth N AllredDepartment of Neurology, Boston Children's Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts.
Alan LevitonDepartment of Neurology, Boston Children's Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts.
ELGAN Study Investigators
Pediatrics and Genetics · USHarvard University · USBoston University · USUniversity of Chicago · USUniversity of North Carolina at Chapel Hill · US

Funding

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0M
SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUG3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2016 to 2024
$7.4M
NICHD NIH HHS P30 HD018655NIH HHS UG3 OD023348NINDS NIH HHS U01 NS040069
6 · The paper itself

Abstract

objectivesTo compare neurocognitive, language, executive function, academic achievement, neurologic and behavioral outcomes, and quality of life at age 10 years in children born extremely preterm who developed bronchopulmonary dysplasia (BPD) to children who did not develop BPD.

methodsThe Extremely Low Gestational Age Newborns study population included 863 children born extremely preterm whose BPD status before discharge was known had an IQ (Differential Ability Scales II [DAS II]) assessment at 10 years. We evaluated the association of BPD with any cognitive (DAS II), executive function (NEuroPSYchological Assessment II), academic achievement (Wechsler Individual Achievement Test-III and Oral and Written Language Scales [OWLS]) as well as social dysfunctions (Social Responsiveness Scale). We used logistic regression models, adjusting for potential confounding factors, to assess the strength of association between the severity of BPD and each outcomes.

resultsThree hundred and seventy-two (43%) children were oxygen-dependent at 36 weeks postconception age, whereas an additional 78 (9%) were also oxygen- and ventilator-dependent. IQ scores 2 or more SDs below the expected mean (ie,

conclusionsAmong 10-year-old children born extremely preterm, those who had BPD were at increased risk of cognitive, language, and executive dysfunctions; academic achievement limitations; social skill deficits; and low scores on assessments of health-related quality of life.

Indexed as

Infant, Extremely PrematureQuality of LifeAcademic SuccessBronchopulmonary DysplasiaChildCognitive DysfunctionExecutive FunctionFemaleFollow-Up StudiesHumansInfant, NewbornIntelligence TestsLanguage Development DisordersMaleNeuropsychological TestsOxygen Inhalation Therapy

Identifiers

PMID29773664
PMCPMC6317639
OpenAlexW2804321277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.