ArticleThe Journal of experimental medicine2018
Bhlhe40 is an essential repressor of IL-10 during
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Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Systematic review of innate immune responses againstFrontiers in immunology · 2024Pooled it
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- A Rapid Active-Latent-Relapse Murine Model of Tuberculosis Based Blood Transcriptional Signature That Distinguishes Disease Stages.International journal of molecular sciences · 2026Article
- REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis.The Journal of experimental medicine · 2026Article
- Role of IL-10 signaling in the circadian control of host response to influenza infection.Mucosal immunology · 2026Article
- Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis.Cell reports · 2025Article
- Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn's disease.The Journal of experimental medicine · 2025Article
- Bhlhe40 Coordinates T Cell Programs with Distinct CD4 and CD8 T Cell Requirements for Anti-PD-1 Versus Anti-CTLA-4.bioRxiv : the preprint server for biology · 2025Article
- BHLHE40 contributes to allergic asthma progression in mice through NRTN downregulation in macrophages.Communications biology · 2025Article
- ATG5 suppresses type I IFN-dependent neutrophil effector functions during Mycobacterium tuberculosis infection in mice.Nature microbiology · 2025Article
- Interleukin-1 receptor antagonist is a conserved early factor for exacerbating tuberculosis susceptibility.bioRxiv : the preprint server for biology · 2025Article
- Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model.Nature communications · 2025Article
- Identification of antigen-presenting cell-T cell interactions driving immune responses to food.Science (New York, N.Y.) · 2025Article
- rBCG-LTAK63 enhances protection against tuberculosis by inducing autophagy and circadian gene regulation.Frontiers in immunology · 2025Article
- Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation.Cell host & microbe · 2024Article
- CD4Immunity · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Jeremy P HuynhDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO.
Chih-Chung LinDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Jacqueline M KimmeyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO.
Nicholas N JarjourDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0001-9400-4448
Elizabeth A SchwarzkopfDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Tara R BradstreetDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Irina ShchukinaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Oleg ShpynovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Casey T WeaverDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-2180-1793
Reshma TanejaDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-2151-2094
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Brian T EdelsonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO bedelson@path.wustl.edu.
Christina L StallingsDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO stallings@wustl.edu.ORCID 0000-0002-2747-5618
Washington University in St. Louis · USNational University of Singapore · SGUniversity of Alabama at Birmingham · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MTRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4MTRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MUNDERSTANDING AUTOREACTIVE T CELL PATHOGENICITYR01AI113118 · NIAID · WASHINGTON UNIVERSITY · PI EDELSON, BRIAN TODD · 2015 to 2019
$1.9MNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIAID NIH HHS R01 AI113118NIAID NIH HHS T32 AI007163NIGMS NIH HHS T32 GM007067NINDS NIH HHS N01 NS002331
Abstract
The cytokine IL-10 antagonizes pathways that control
Indexed as
Adaptive ImmunityAnimalsBase SequenceBasic Helix-Loop-Helix ProteinsGenetic LociHomeodomain ProteinsImmunity, InnateInflammationInterleukin-10LymphocytesMice, Inbred C57BLModels, BiologicalMyeloid CellsNeutrophilsProtein BindingRepressor ProteinsBasic Helix-Loop-Helix ProteinsBhlhe40 protein, mouseHomeodomain ProteinsInterleukin-10Repressor Proteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.