Evidence map›Paper›PMID 29773568›Full record

ArticleAJNR. American journal of neuroradiology2018

Radiation-Induced Myelitis: Initial and Follow-Up MRI and Clinical Features in Patients at a Single Tertiary Care Institution during 20 Years.

M Khan, P Ambady, D Kimbrough, T Shoemaker, S Terezakis, J Blakeley, S D Newsome, I Izbudak

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Magnetic Resonance Imaging for Spine Emergencies.Magnetic resonance imaging clinics of North America · 2022
    Review
  8. Review
  9. Neurological side effects of radiation therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Review
  10. Article
  11. A brief case series of radiation associated myelopathy.Neurosciences (Riyadh, Saudi Arabia) · 2021
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M KhanDivision of Neuroradiology, Russell H. Morgan Department of Radiology (M.K., I.I.), Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-3807-1387
P AmbadyFrom the Brain Cancer Program (P.A., J.B., S.T.).ORCID 0000-0003-4812-0581
D KimbroughDivision of Neuroimmunology and Neuroinfectious Diseases, Department of Neurology (D.K., T.S., S.D.N.).ORCID 0000-0001-9194-1452
T ShoemakerDivision of Neuroimmunology and Neuroinfectious Diseases, Department of Neurology (D.K., T.S., S.D.N.).ORCID 0000-0002-1085-6860
S TerezakisFrom the Brain Cancer Program (P.A., J.B., S.T.).ORCID 0000-0003-4933-6712
J BlakeleyFrom the Brain Cancer Program (P.A., J.B., S.T.).ORCID 0000-0002-1049-0993
S D NewsomeDivision of Neuroimmunology and Neuroinfectious Diseases, Department of Neurology (D.K., T.S., S.D.N.).ORCID 0000-0002-5284-4681
I IzbudakDivision of Neuroradiology, Russell H. Morgan Department of Radiology (M.K., I.I.), Johns Hopkins University School of Medicine, Baltimore, Maryland iizbuda1@jhmi.edu.ORCID 0000-0002-9845-5171

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelitis is a rare complication of radiation exposure to the spinal cord and is often a diagnosis of exclusion. A retrospective review of clinical records and serial imaging was performed to identify subjects with documented myelitis and a history of prior radiation. Eleven patients fulfilled the inclusion criteria. All patients had longitudinally extensive cord involvement with homogeneous precontrast T1 hyperintense signal in the adjacent vertebrae, corresponding to the radiation field. T2 signal abnormalities involving the central two-thirds of the cord were seen in 6/11 patients (55%). The degree of cord expansion and contrast enhancement was variable but was seen in 6 (54%) and 5 (45%) patients, respectively. On follow-up, 2 patients developed cord atrophy, while complete resolution was noted in 1. Clinical improvement was noted in 5 patients, with symptom progression in 2 patients. Our results suggest that radiation myelitis is neither universally progressive nor permanent, and some radiographic and clinical improvement may occur.

Indexed as

AdolescentAdultChildDisease ProgressionFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMyelitisRadiation InjuriesRadiotherapyRetrospective StudiesTertiary Health CareYoung Adult

Identifiers

PMID29773568
PMCPMC7410541

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.