ArticleGenetics2018
Establishment of Locally Adapted Mutations Under Divergent Selection.
Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Maintaining Local Adaptation Is Key for Evolutionary Rescue and Long-Term Persistence of Populations Experiencing Habitat Loss and a Changing Environment.Evolutionary applications · 2025Article
- Establishment of a locally adaptive allele in multidimensional continuous space.G3 (Bethesda, Md.) · 2025Article
- Article
- Sexual imprinting leads to speciation in locally adapted populations.Ecology and evolution · 2022Article
- Article
- Review
- Establishment of a new sex-determining allele driven by sexually antagonistic selection.G3 (Bethesda, Md.) · 2021Article
- Multi-dimensional diffusion process of allele frequencies in population genetics.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2021Review
- The Evolutionary Dynamics of a Genetic Barrier to Gene Flow: From the Establishment to the Emergence of a Peak of Divergence.Genetics · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the first analytical closed-form approximation for arbitrary migration rate to appear in the literature. We find that the establishment probability lies between the weak and the strong migration limits if we condition the origin of the mutation to the deme where it is advantageous. This is not the case when we condition the mutation to first occur in a deme where it is disadvantageous. In this case we find that an intermediate migration rate maximizes the probability of establishment. We extend our results to the cases of multiple demes, two demes with asymmetric rates of gene flow, and asymmetric carrying capacities. The latter case allows us to illustrate how density regulation can affect establishment probabilities. Finally, we use our results to investigate the role of gene flow on the rate of local adaptation and identify cases in which intermediate amounts of gene flow facilitate the rate of local adaptation as compared to two populations without gene flow.
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