ArticleParkinsonism & related disorders2018
Increased foot strike variability in Parkinson's disease patients with freezing of gait.
Article in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05107531 (Investigation of Gait, Foot Pressure Distribution and Balance in Parkinson's Patients With Motor Freezing), which is not on this map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Gait, Foot Pressure Distribution and Balance in Parkinson's Patients With Motor Freezing
Who cites it
29 citing papers in PubMed.
- Lessons Learned From a Delayed-Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease.Annals of clinical and translational neurology · 2026Trial
- Effect of freezing phenomenon on gait parameters and pedobarographic pressure distribution in patients with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Sixty hertz STN-DBS and L-Dopa reduces gait variability in parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Deep Learning-Based Prediction of Freezing of Gait in Parkinson's Disease With the Ensemble Channel Selection Approach.Brain and behavior · 2025Article
- Gait-Guard: Turn-aware Freezing of Gait Detection for Non-intrusive Intervention Systems....IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies. IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies · 2024Article
- Knowledge mapping of freezing of gait in Parkinson's disease: a bibliometric analysis.Frontiers in neuroscience · 2024Article
- Investigating spatiotemporal and kinematic gait parameters in individuals with Parkinson's disease with a history of freezing of gait and exploring the effects of dopaminergic therapy on freezing of gait subtypes.Frontiers in neuroscience · 2024Article
- Detection of freezing of gait in Parkinson's disease from foot-pressure sensing insoles using a temporal convolutional neural network.Frontiers in aging neuroscience · 2024Article
- Carpets with visual cues can improve gait in Parkinson's disease patients: may be independent of executive function.European journal of medical research · 2023Article
- FoG-Finder: Real-time Freezing of Gait Detection and Treatment....IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies. IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies · 2023Article
- Gait Declines Differentially in, and Improves Prediction of, People with Parkinson's Disease Converting to a Freezing of Gait Phenotype.Journal of Parkinson's disease · 2023Article
- Levodopa responsive gait dynamics in OFF- and ONOFF-state freezing of gait in Parkinson's disease.Clinical parkinsonism & related disorders · 2023Article
- Increased foot strike variability during turning in Parkinson's disease patients with freezing of gait.Gait & posture · 2022Article
- Feasibility of telemedicine research visits in people with Parkinson's disease residing in medically underserved areas.Journal of clinical and translational science · 2022Article
- Article
- Atypical Gait Cycles in Parkinson's Disease.Sensors (Basel, Switzerland) · 2021Article
- Early Detection of Freezing of Gait during Walking Using Inertial Measurement Unit and Plantar Pressure Distribution Data.Sensors (Basel, Switzerland) · 2021Article
- Utility of objective gait measures in levodopa-unresponsive freezing in Parkinson's.Clinical case reports · 2021Article
- Impact of Footwear and Foot Deformities in patients with Parkinson's disease: A Case-Series Study.International journal of medical sciences · 2021Observational
- The Neurodevelopmental and Motor Phenotype of SCA21 (ATX-TMEM240).Journal of child neurology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionFreezing of gait (FOG) is a debilitating, late motor complication of Parkinson's disease (PD) that occurs in 50-80% of patients. Gait freezing significantly worsens quality of life by decreasing mobility and increasing falls. Studies have shown that patients with episodic freezing episodes also have deficits in continuous gait. We evaluated whether there was an objective gait correlate to the increased stumbling reported by many patients with gait freezing.
methodsPD subjects and healthy controls (HC) were enrolled after IRB approval. Subjects with more than 1 fall/day or a Montreal Cognitive Assessment score <10 were excluded. Subjects walked at their normal pace, 8 lengths of a 20 × 4 foot pressure-sensor mat. Data was collected and analyzed using PKMAS software (Protokinetics) and statistical analysis performed using SPSS 22 (IBM).
results72 age matched subjects (22 PD FOG, 27 PD no-FOG, and 23 HC) were enrolled. Disease duration and Hoehn & Yahr scores were not significantly different between the PD groups. Mean dimensions of foot strike were not significantly different between groups, but PD FOG subjects had increased step-to-step variability in foot strike as measured by the percent coefficient of variation (%CV) in foot strike length compared to PD no-FOG and HC, independent of stride velocity. In PD no-FOG subjects, fallers also had higher variability in foot strike length compared to non-fallers.
conclusionPD subjects with FOG had increased variability in foot strike suggesting that in addition to stride length variability, foot strike variability could contribute to imbalance leading to falls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.