ArticleMolecules (Basel, Switzerland)2018
Optimisation of Ethanol-Reflux Extraction of Saponins from Steamed Panax notoginseng by Response Surface Methodology and Evaluation of Hematopoiesis Effect.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Optimization of the extraction process of Sanhuang Qingre Formula by integrating response surface methodology, grey correlation analysis, and machine learning.Scientific reports · 2026Article
- Developments and Assessments of Crude Tea Saponin-Incorporated Silica Nanoparticles for Their Bioactivity Improvement.Journal of functional biomaterials · 2025Article
- Extraction of saponins from soapnut and their application in controlling ammonia and particulate matter.RSC advances · 2025Article
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- Preparation ofInternational journal of food science · 2025Article
- Extraction and Purification of Flavonoids and Antiviral and Antioxidant Activities ofMolecules (Basel, Switzerland) · 2024Article
- Effects of steaming process on rare saponins and efficacy ofChinese herbal medicines · 2024Review
- Optimization of Ethanol Extraction Technology for Yujin Powder Using Response Surface Methodology with a Box-Behnken Design Based on Analytic Hierarchy Process-Criteria Importance through Intercriteria Correlation Weight Analysis and Its Safety Evaluation.Molecules (Basel, Switzerland) · 2023Article
- Study on the regulatory effect of Panax notoginseng saponins combined with bone mesenchymal stem cell transplantation on IRAK1/TRAF6-NF-κB pathway in patients with diabetic cutaneous ulcers.Journal of orthopaedic surgery and research · 2023Article
- An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves ofFrontiers in nutrition · 2022Article
- Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- SteamedFrontiers in pharmacology · 2022Article
- Extraction Optimization of Astragaloside IV by Response Surface Methodology and Evaluation of Its Stability during Sterilization and Storage.Molecules (Basel, Switzerland) · 2021Article
- Analyzing Active Constituents and Optimal Steaming Conditions Related to the Hematopoietic Effect of SteamedBioMed research international · 2020Article
- Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis.Molecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aims to optimize the ethanol-reflux extraction conditions for extracting saponins from steamed Panax notoginseng (SPN). Four variables including the extraction time (0.5⁻2.5 h), ethanol concentration (50⁻90%), water to solid ratio (W/S, 8⁻16), and times of extraction (1⁻5) were investigated by using the Box-Behnken design response surface methodology (BBD-RSM). For each response, a second-order polynomial model with high R² values (>0.9690) was developed using multiple linear regression analysis and the optimum conditions to maximize the yield (31.96%), content (70.49 mg/g), and antioxidant activity (EC
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Registered trials
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