ReviewInternational journal of molecular sciences2018
Overview of Cadmium Thyroid Disrupting Effects and Mechanisms.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 205 citations in OpenAlex.
- The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review.Current molecular medicine · 2025Pooled it
- Endocrine-disrupting chemicals (EDCs) and cancer: new perspectives on an old relationship.Journal of endocrinological investigation · 2023Pooled it
- Dibutyl phthalate exposure induces thyroid toxicity through follicular cell pyroptosisAnnals of medicine · 2026Article
- Differential Sensitivity of Endocrine and Non-Endocrine Tissues to Cadmium-Induced Lipid Peroxidation and the Protective Role of Melatonin.International journal of molecular sciences · 2026Article
- Heavy Metal Air Pollution: Human Health Effects and Nanomaterial Strategies for Monitoring and Remediation.Biological trace element research · 2026Review
- The Thyroid Under Pressure: Heavy Metals, Endocrine Disruptors and Translational Insights into Carcinogenesis and Thyroid Dysfunctions.International journal of molecular sciences · 2026Review
- Bio and Geno-toxic Activities of Cadmium- Arsenic Salts Combination And/or Fluoride in Female Rats Confirmed by Molecular Docking.Biological trace element research · 2026Article
- Minimal Risk Doses of Cadmium Exposure Induce Histological and Functional Alterations in the Brown Adipose Tissue of Wistar Rats.Biological trace element research · 2026Article
- Multi-Targeted Mechanisms of Phytochemicals in Mitigating Cadmium-Induced Breast Cancer.Medicines (Basel, Switzerland) · 2026Review
- Development and validation of a novel senescence-associated gene signature for prediction of survival and endocrine-disrupting chemicals in bladder cancer.Discover oncology · 2026Article
- Application of Modulators of CaInternational journal of molecular sciences · 2025Article
- Association between heavy metals and risk of cardiovascular diseases in US adults with prediabetes from NHANES 2011-2018.BMC public health · 2025Article
- Effects of Trace Elements on Endocrine Function and Pathogenesis of Thyroid Diseases-A Literature Review.Nutrients · 2025Review
- Cadmium Exposure was Associated with Sex-Specific Thyroid Dysfunction: Consistent Evidence from Two Independent Cross-Sectional Studies Based on Urinary and Blood Cadmium Measurements.Biological trace element research · 2025Article
- Association between toxic heavy metals and noncancerous thyroid disease: a scoping review.PeerJ · 2025Article
- Article
- Evaluation of the cognitive, physiological, and biomarker effects of heavy metal exposure in Wistar rats.Veterinary world · 2024Article
- Mechanisms of Phytoremediation by Resveratrol against Cadmium Toxicity.Antioxidants (Basel, Switzerland) · 2024Review
- Exploring temporal trends and influencing factors for thyroid cancer in Guangzhou, China: 2004-2018.Endocrine · 2024Article
- Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid.Heliyon · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.