Evidence map›Paper›PMID 29772707›Full record

ArticleInternational journal of molecular sciences2018

PIMT/NCOA6IP Deletion in the Mouse Heart Causes Delayed Cardiomyopathy Attributable to Perturbation in Energy Metabolism.

Yuzhi Jia, Ning Liu, Navin Viswakarma, Ruya Sun, Mathew J Schipma, Meng Shang, Edward B Thorp, Yashpal S Kanwar, Bayar Thimmapaya, Janardan K Reddy

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuzhi JiaDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. y-jia@northwestern.edu.
Ning LiuDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. nliu2224@163.com.
Navin ViswakarmaDepartment of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612, USA. navinv@uic.edu.
Ruya SunDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. ruya.sun@northwestern.edu.
Mathew J SchipmaNext Generation Sequencing Core Facility, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. m-schipma@northwestern.edu.
Meng ShangFeinberg Cardiovascular Research Institute and Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. meng.shang@northwestern.edu.
Edward B ThorpDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. ebthorp@northwestern.edu.
Yashpal S KanwarDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. y-kanwar@northwestern.edu.
Bayar ThimmapayaDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. b-thimmapaya@northwestern.edu.ORCID 0000-0001-9842-5346
Janardan K ReddyDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. jkreddy@northwestern.edu.
Northwestern University · USUniversity of Illinois Chicago · US

Funding

Pathogenesis of Diabetic NephropathyR01DK060635 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QUAGGIN, SUSAN E. · 2002 to 2023
$6.6M
Efferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic HeartR01HL122309 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THORP, EDWARD BENJAMIN · 2014 to 2024
$5.0M
TAM-Kinases in TransplantR01HL139812 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, XUNRONG, THORP, EDWARD BENJAMIN · 2018 to 2021
$2.4M
Transcriptional Coactivators in Liver FunctionR01DK083163 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI REDDY, JANARDAN K. · 2009 to 2013
$1.7M
Med1 in Liver Metabolism, Regeneration and CancerR01DK097249 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JIA, YUZHI, REDDY, JANARDAN K. · 2013 to 2017
$1.7M
NHLBI NIH HHS R01 HL139812NIDDK NIH HHS R01 DK060635NIDDK NIH HHS R01 DK083163NIDDK NIH HHS R01 DK097249
6 · The paper itself

Abstract

PIMT/NCOA6IP, a transcriptional coactivator PRIP/NCOA6 binding protein, enhances nuclear receptor transcriptional activity. Germline disruption of PIMT results in early embryonic lethality due to impairment of development around blastocyst and uterine implantation stages. We now generated mice with Cre-mediated cardiac-specific deletion of PIMT (csPIMT

Indexed as

Energy MetabolismGene DeletionAnimalsCardiomyopathiesCardiomyopathy, DilatedDisease Models, AnimalFibrosisGene ExpressionGlucoseGlycogenMiceMice, KnockoutMitochondriaMyocardial ContractionMyocardiumMyocytes, CardiacGlucoseGlycogenNCOA6 protein, humanNuclear Receptor CoactivatorsPCMT1 protein, humanProtein D-Aspartate-L-Isoaspartate Methyltransferasecardiac fibrosisdilated cardiomyopathyenergy metabolismPIMT/NCOA6IPPPARαPRIP/NCOA6

Identifiers

PMID29772707
PMCPMC5983783
OpenAlexW2803628887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.