ReviewNanomaterials (Basel, Switzerland)2018
Periodontal Tissues, Maxillary Jaw Bone, and Tooth Regeneration Approaches: From Animal Models Analyses to Clinical Applications.
Review in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Histologic and Histomorphometric Evaluation of Bone Regeneration Using Human Allogeneic Bone Graft with or Without Mesenchymal Stem Cell-Conditioned Media in a Rabbit Calvarial Defect Model.Journal of functional biomaterials · 2025Article
- Gels as adjuvant to non-surgical periodontal therapy: A systematic review and meta-analysis.Heliyon · 2023Review
- Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives.Journal of functional biomaterials · 2023Review
- Article
- Advances of Hydrogel Therapy in Periodontal Regeneration-A Materials Perspective Review.Gels (Basel, Switzerland) · 2022Review
- Review
- Human Umbilical Cord Mesenchymal Stem Cells: Current Literature and Role in Periodontal Regeneration.Cells · 2022Review
- Investigation of Patient-Specific Maxillofacial Implant Prototype Development by Metal Fused Filament Fabrication (MFDentistry journal · 2021Article
- Nanomaterials Application in Endodontics.Materials (Basel, Switzerland) · 2021Review
- Eruption of Bioengineered Teeth: A New Approach Based on a Polycaprolactone Biomembrane.Nanomaterials (Basel, Switzerland) · 2021Article
- A New Polycaprolactone-Based Biomembrane Functionalized with BMP-2 and Stem Cells Improves Maxillary Bone Regeneration.Nanomaterials (Basel, Switzerland) · 2020Article
- Recent Progress in Carbon Nanotube Polymer Composites in Tissue Engineering and Regeneration.International journal of molecular sciences · 2020Review
- Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2020Review
- A Multifunctional Antibacterial and Osteogenic Nanomedicine: QAS-Modified Core-Shell Mesoporous Silica Containing Ag Nanoparticles.BioMed research international · 2020Article
- Three-Dimensional Micro-Computed Tomography of the Adult Mouse Ovary.Frontiers in cell and developmental biology · 2020Article
- Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects.Nanomaterials (Basel, Switzerland) · 2019Review
- Application of Chitosan in Bone and Dental Engineering.Molecules (Basel, Switzerland) · 2019Review
- Review
- Preparation and Application of Hybrid Nanomaterials.Nanomaterials (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review encompasses different pre-clinical bioengineering approaches for periodontal tissues, maxillary jaw bone, and the entire tooth. Moreover, it sheds light on their potential clinical therapeutic applications in the field of regenerative medicine. Herein, the electrospinning method for the synthesis of polycaprolactone (PCL) membranes, that are capable of mimicking the extracellular matrix (ECM), has been described. Furthermore, their functionalization with cyclosporine A (CsA), bone morphogenetic protein-2 (BMP-2), or anti-inflammatory drugs' nanoreservoirs has been demonstrated to induce a localized and targeted action of these molecules after implantation in the maxillary jaw bone. Firstly, periodontal wound healing has been studied in an induced periodontal lesion in mice using an ibuprofen-functionalized PCL membrane. Thereafter, the kinetics of maxillary bone regeneration in a pre-clinical mouse model of surgical bone lesion treated with BMP-2 or BMP-2/Ibuprofen functionalized PCL membranes have been analyzed by histology, immunology, and micro-computed tomography (micro-CT). Furthermore, the achievement of innervation in bioengineered teeth has also been demonstrated after the co-implantation of cultured dental cell reassociations with a trigeminal ganglia (TG) and the cyclosporine A (CsA)-loaded poly(lactic-co-glycolic acid) (PLGA) scaffold in the jaw bone. The prospective clinical applications of these different tissue engineering approaches could be instrumental in the treatment of various periodontal diseases, congenital dental or cranio-facial bone anomalies, and post-surgical complications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.