Evidence map›Paper›PMID 29772675›Full record

ArticleInternational journal of molecular sciences2018

Silencing Stem Cell Factor Gene in Fibroblasts to Regulate Paracrine Factor Productions and Enhance c-Kit Expression in Melanocytes on Melanogenesis.

Pin-Hui Li, Li-Heng Liu, Cheng-Chung Chang, Rong Gao, Chung-Hang Leung, Dik-Lung Ma, Hui-Min David Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. The Skin-Brain Axis: From UV and Pigmentation to Behaviour Modulation.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. FermentedMolecules (Basel, Switzerland) · 2023
    Article
  10. Article
  11. Review
  12. [Cutaneous hyperpigmentation as a manifestation in acute on chronic liver failure].Revista medica del Instituto Mexicano del Seguro Social · 2022
    Article
  13. Review
  14. Review
  15. Dermal Pathology in Melasma: An Update Review.Clinical, cosmetic and investigational dermatology · 2022
    Review
  16. [Research progress on the mechanism of wound skin dys- pigmentation after burns].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021
    Review
  17. Insights into the Pathogenesis of NF1-Associated Neoplasms.JID innovations : skin science from molecules to population health · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Pin-Hui LiDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. s27159@gmail.com.
Li-Heng LiuDepartment of Life Science, National Chung Hsing University, Taichung City 402, Taiwan. arthur851213@gmail.com.
Cheng-Chung ChangGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 402, Taiwan. ccchang555@dragon.nchu.edu.tw.
Rong GaoJiaxing Deqin Biotechnology Department, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, Zhejiang, China. gaorong709@naver.com.
Chung-Hang LeungState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China. duncanleung@umac.mo.
Dik-Lung MaDepartment of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong 22100, China. edmondma@hkbu.edu.hk.
Hui-Min David WangGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 402, Taiwan. davidw@dragon.nchu.edu.tw.ORCID 0000-0002-5162-9752
Kaohsiung Medical University · TWNational Chung Hsing University · TWHong Kong Baptist University · HKTsinghua University · CNUniversity of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanogenesis is a complex physiological mechanism involving various paracrine factors. Skin cells such as keratinocytes, fibroblasts, and melanocytes communicate with one another through secreted regulators, thereby regulating the melanocytes' bio-functions. The stem cell factor (SCF) is a paracrine factor produced by fibroblasts, and its receptor, c-kit, is expressed on melanocytes. Binding of SCF to c-kit activates autophosphorylation and tyrosine kinase to switch on its signal transmission.

Indexed as

Gene SilencingParacrine CommunicationCell ProliferationFibroblastsGene Knockdown TechniquesHumansMelaninsMelanocytesProto-Oncogene Proteins c-kitRNA InterferenceStem Cell FactorUltraviolet RaysMelaninsProto-Oncogene Proteins c-kitStem Cell Factorfibroblastsmelaninmelanocytesparacrine factorsstem cell factor

Identifiers

PMID29772675
PMCPMC5983634
OpenAlexW2804972113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.