Evidence map›Paper›PMID 29772645›Full record

ArticleMarine drugs2018

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate

Sara Carpi, Beatrice Polini, Giulio Poli, Gabriela Alcantara Barata, Stefano Fogli, Antonella Romanini, Tiziano Tuccinardi, Graziano Guella, Francesco Paolo Frontini, Paola Nieri and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Marine Compounds for Melanoma Treatment and Prevention.International journal of molecular sciences · 2022
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Tumor Suppressor Role of hsa-miR-193a-3p and -5p in Cutaneous Melanoma.International journal of molecular sciences · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Akt pathway in oncology therapy and beyond (Review).International journal of oncology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sara CarpiDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy. sara.carpi@unipi.it.ORCID 0000-0002-3291-9009
Beatrice PoliniDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy. beatrice.polini@farm.unipi.it.
Giulio PoliDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. giulio.poli@unisi.it.
Gabriela Alcantara BarataDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy. gabriela.alcantara@farm.unipi.it.
Stefano FogliDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy. stefano.fogli@unipi.it.
Antonella RomaniniMedical Oncology Unit, University Hospital of Pisa, via Roma 67, 56126 Pisa, Italy. amvromanini@gmail.com.
Tiziano TuccinardiDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy. tiziano.tuccinardi@unipi.it.ORCID 0000-0002-6205-4069
Graziano GuellaBioorganic Chemistry Laboratory, Department of Physics, University of Trento, Via Sommarive 4, 38123 Povo, Trento, Italy. graziano.guella@unitn.it.ORCID 0000-0002-1799-0819
Francesco Paolo FrontiniUnit of Zoology-Anthropology, Department of Biology, University of Pisa, via A. Volta 4, 56126 Pisa, Italy. francesco.paolo.frontini@unipi.it.
Paola NieriDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy. paola.nieri@unipi.it.
Graziano Di GiuseppeUnit of Zoology-Anthropology, Department of Biology, University of Pisa, via A. Volta 4, 56126 Pisa, Italy. graziano.di.giuseppe@unipi.it.
University of Pisa · ITAzienda Ospedaliera Universitaria Pisana · ITUniversity of Siena · ITUniversity of Trento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous melanoma is the most serious type of skin cancer, so new cytotoxic weapons against novel targets in melanoma are of great interest. Euplotin C (EC), a cytotoxic secondary metabolite of the marine ciliate

Indexed as

ApoptosisAquatic OrganismsCalcium Channel AgonistsCell Line, TumorDantroleneDrug Evaluation, PreclinicalEuplotesHumansMAP Kinase Signaling SystemMelanomaOncogene Protein v-aktRyanodine Receptor Calcium Release ChannelSesquiterpenesSkin NeoplasmsCalcium Channel AgonistsDantroleneeuplotin COncogene Protein v-aktRyanodine Receptor Calcium Release ChannelSesquiterpenescutaneous melanomaEuplotes crassuseuplotin Cmarine drugprotistryanodine receptorsesquiterpenoid

Identifiers

PMID29772645
PMCPMC5983297
OpenAlexW2804281263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.