Evidence map›Paper›PMID 29772461›Full record

ReviewBiomaterials2018

Quickening: Translational design of resorbable synthetic vascular grafts.

Chelsea E T Stowell, Yadong Wang

Abstract readReview
In one paragraph

Review in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chelsea E T StowellMeinig School of Biomedical Engineering, Cornell University, USA.
Yadong WangMeinig School of Biomedical Engineering, Cornell University, USA. Electronic address: yw839@cornell.edu.

Funding

Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Compliant and strong small arteries engineered in vitroR01HL089658 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, YADONG · 2007 to 2016
$3.4M
Computational Model Driven Design of Tissue Engineered Vascular GraftsR01HL128602 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2015 to 2018
$2.2M
NHLBI NIH HHS R01 HL089658NHLBI NIH HHS R01 HL128602NHLBI NIH HHS T32 HL076124
6 · The paper itself

Abstract

Traditional tissue-engineered vascular grafts have yet to gain wide clinical use. The difficulty of scaling production of these cell- or biologic-based products has hindered commercialization. In situ tissue engineering bypasses such logistical challenges by using acellular resorbable scaffolds. Upon implant, the scaffolds become remodeled by host cells. This review describes the scientific and translational advantages of acellular, synthetic vascular grafts. It surveys in vivo results obtained with acellular synthetics over their fifty years of technological development. Finally, it discusses emerging principles, highlights strategic considerations for designers, and identifies questions needing additional research.

Indexed as

Blood Vessel ProsthesisAnimalsBiocompatible MaterialsCell AdhesionCell ProliferationExtracellular MatrixHumansMyocytes, Smooth MusclePolymersTissue ScaffoldsVascular PatencyBiocompatible MaterialsPolymersBiodegradableDegradable vascular graftHost remodelingIn situ tissue engineering

Identifiers

PMID29772461
PMCPMC6492619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.