Evidence map›Paper›PMID 29772409›Full record

ReviewCurrent opinion in immunology2018

Lymphatics in the liver.

Masatake Tanaka, Yasuko Iwakiri

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Chyloperitoneum in a toddler on peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2025
    Article
  6. Diagnosis and Treatment of Postoperative Hepatic Lymphorrhea.Interventional radiology (Higashimatsuyama-shi (Japan) · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Angiogenesis-An Emerging Role in Organ Fibrosis.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Masatake TanakaSection of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Yasuko IwakiriSection of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: yasuko.iwakiri@yale.edu.
Yale University · US

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
The role of Kupffer cells in alcohol-induced liver diseaseR01AA025342 · NIAAA · YALE UNIVERSITY · PI IWAKIRI, YASUKO · 2017 to 2021
$1.9M
Mechanisms of Alcohol-Induced Hepatic OsteodystrophyR21AA023607 · NIAAA · YALE UNIVERSITY · PI IWAKIRI, YASUKO · 2016 to 2017
$440k
Alcohol metabolism in liver sinusoidal endothelial cellsR21AA023599 · NIAAA · YALE UNIVERSITY · PI IWAKIRI, YASUKO · 2015 to 2016
$437k
NIAAA NIH HHS R01 AA025342NIAAA NIH HHS R21 AA023599NIAAA NIH HHS R21 AA023607NIDDK NIH HHS P30 DK034989
6 · The paper itself

Abstract

The liver is the largest lymph producing organ. A significant increase in the number of hepatic lymphatic vessels, or lymphangiogenesis, has been reported in various liver diseases, including, but not limited to, cirrhosis, viral hepatitis and hepatocellular carcinoma. Despite its apparent relevance in healthy and diseased livers as these and other observations indicate, the hepatic lymphatic system has been poorly studied. With knowledge of the lymphatic system in other organs and tissues incorporated, this review article addresses the current knowledge of the hepatic lymphatic system and the potential role of lymphatic endothelial cells in the health and the disease of the liver and concludes with a brief description on future directions of the study of the hepatic lymphatic system.

Indexed as

AnimalsCarcinoma, HepatocellularEndothelial CellsHepatitis, Viral, HumanHumansLiverLiver CirrhosisLymphangiogenesisLymphatic Vessels

Identifiers

PMID29772409
PMCPMC6986420
OpenAlexW2799952247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.