Evidence map›Paper›PMID 29772265›Full record

ArticleToxicology letters2018

Administration of low dose triclosan to pregnant ewes results in placental uptake and reduced estradiol sulfotransferase activity in fetal liver and placenta.

Erin N Jackson, Laura Rowland-Faux, Margaret O James, Charles E Wood

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erin N JacksonDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA.
Laura Rowland-FauxDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA.
Margaret O JamesDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA. Electronic address: mojames@ufl.edu.
Charles E WoodDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, FL, 32610, USA.
University of Florida · US

Funding

Fetal Endocrine Disruption by TriclosanR21ES020545 · NIEHS · UNIVERSITY OF FLORIDA · PI JAMES, MARGARET OLIVE, WOOD, CHARLES E · 2011 to 2012
$403k
NIEHS NIH HHS R21 ES020545
6 · The paper itself

Abstract

Sulfonation is a major pathway of estrogen biotransformation with a role in regulating estrogen homeostasis in humans and sheep. Previous in vitro studies found that triclosan is an especially potent competitive inhibitor of ovine placental estrogen sulfotransferase, with K

Indexed as

AnimalsAnti-Infective Agents, LocalEnzyme InhibitorsEstradiolFemaleFetusInfusions, IntravenousLiverMaternal ExposurePlacentaPregnancySheep, DomesticSulfotransferasesTissue DistributionToxicokineticsTriclosanAnti-Infective Agents, LocalEnzyme InhibitorsEstradiolestradiol-17 beta sulfotransferaseSulfotransferasesTriclosanEstradiol sulfonationPlacentaSulfotransferase inhibitionTriclosan infusion

Identifiers

PMID29772265
PMCPMC6026481
OpenAlexW2803157964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.