ArticlePsycho-oncology2018
Child symptoms, parent behaviors, and family strain in long-term survivors of childhood acute lymphoblastic leukemia.
Article in Psycho-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137111 (Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Symptom networks of internalizing and externalizing problems in children with leukemia: a network analysis and computer-simulated intervention study.BMC psychology · 2026Article
- Psychosocial functioning and friendship quality among school-aged pediatric brain tumor survivors.Journal of pediatric psychology · 2026Article
- Daily Symptom Home Monitoring Decreases Hospital Readmissions in Children and Young Adults With Acute Lymphoblastic Leukemia.Cancer medicine · 2026Article
- Family environment variables and related health outcomes in children and adolescent and younger adults affected by cancer: a scoping review.Frontiers in psychology · 2026Review
- Changes in survival probabilities and mortality risks among population living with Down syndrome born 1967-2018: a Norwegian registry-based study.BMC public health · 2025Article
- "Everything I do is for your own good!" Exploring the real experience of family support for cancer survivors' return-to-work in China: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Multilevel Characteristics of Cumulative Symptom Burden in Young Survivors of Childhood Cancer.JAMA network open · 2024Article
- Multilevel Social Determinants of Patient-Reported Outcomes in Young Survivors of Childhood Cancer.Cancers · 2024Article
- It's about living a normal life: parents' quality of life when their child has a life-threatening or life-limiting condition - a qualitative study.BMC palliative care · 2024Article
- Caregivers matter: Neurological vulnerability for pediatric brain tumor survivors.Neuro-oncology practice · 2023Article
- Pediatric Cancer Survivorship: Impact Upon Hair Cortisol Concentration and Family Functioning.Journal of clinical psychology in medical settings · 2022Article
- A Review of Patient-Reported Outcome Measures in Childhood Cancer.Children (Basel, Switzerland) · 2022Review
- Quality of life in mothers and fathers of children treated for acute lymphoblastic leukaemia in Sweden, Finland and Denmark.British journal of haematology · 2022Article
- Functioning of Children and Adolescents with Cancer.International journal of environmental research and public health · 2022Observational
- Recommended scoring approach for the pediatric patient-reported outcomes version of the Common Terminology Criteria for Adverse Events.Pediatric blood & cancer · 2022Article
- The Symptom Experience in Pediatric Cancer: Current Conceptualizations and Future Directions.Current oncology reports · 2022Review
- Psychosocial risk, symptom burden, and concerns in families affected by childhood cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- The predictive trifecta? Fatigue, pain, and anxiety severity forecast the suffering profile of children with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- In the name of the family? Against parents' refusal to disclose prognostic information to children.Medicine, health care, and philosophy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveHow family environment and parental factors affect health status and symptoms in childhood cancer survivors is understudied. We examined the influence of family cohesion, parent distress, and overprotection on child symptom burden and health-related quality of life (HRQOL) and family strain in survivors of childhood acute lymphoblastic leukemia.
methodsParents of 213 children treated with chemotherapy only completed a survey when survivors were at least 5-year postdiagnosis. Family Environment Scale, Brief Symptom Inventory-18, Parent Protection Scale, Pediatric Quality of Life Inventory, and Impact on Family were used to assess family cohesion, parental distress, overprotection, child symptom burden and HRQOL, and family strain, respectively. Path analysis was conducted to quantify effects of family cohesion on family strain through parental distress, overprotection, child symptoms, and HRQOL.
resultsLower family cohesion (β = 0.06, 95% CI, 0.01-0.13), higher parental distress (β = 0.35, 95% CI, 0.20-0.45), and overprotection (β = 0.17, 95% CI, 0.01-0.32) were associated with more child symptom burden. More symptom burden were associated with poorer child HRQOL (β = 0.66, 95% CI, 0.57-0.75), which in turn was associated with more family strain (β = 0.11, 95% CI, 0.01-0.22). Lower maternal education was associated with overprotection (β = -0.23, 95% CI, -0.33 to -0.12), more child symptoms (β = -0.30, 95% CI, -0.41 to -0.16), poorer child HRQOL (β = -0.36, 95% CI, -0.46 to -0.21), and more family strain (β = -0.15, 95% CI, -0.23 to -0.08).
conclusionsFamily and parental factors contributed to health outcomes of childhood acute lymphoblastic leukemia survivors. Interventions to enhance family cohesion, decrease parental distress and overprotection, and ameliorate child symptoms may improve family functioning.
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Registered trials
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