ArticlePloS one2018
Development and characterization of an oral multispecies biofilm implant flow chamber model.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- The immune-microbe-metal triad: a vicious cycle driving biomaterial corrosion in the oral inflammatory microenvironment.Bioactive materials · 2027Review
- Commensal microbiota-coated biohybrid implants induce antibiofilm, osteogenic, and immunomodulatory responses in a human 3D immunocompetent model.Bioactive materials · 2026Article
- Unlocking miniature brilliance: micro/nanorobots for advanced dental theranostics.Journal of nanobiotechnology · 2026Review
- Alternative Approach to the Synthesis of Vinyl Ester Resins-Composites and Their Biomedical Application.Polymers · 2025Article
- Biocompatible liquid-infused titanium minimizes oral biofilm adhesion in flow chamber and 3D implant-tissue-biofilmBioactive materials · 2025Article
- Label-free distinction of implant infection-associated bacterial biofilms by Mueller matrix polarimetry.Journal of biomedical optics · 2025Article
- Evaluation of early bacterial adhesion on CAD/CAM dental materials: an in situ study.Odontology · 2025Article
- Influence of species composition and cultivation condition on peri-implant biofilm dysbiosisFrontiers in oral health · 2025Article
- Biosynthesis and Characterization of Silver Nanoparticles and Simvastatin Association in Titanium Biofilms.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Optically accessible, 3D-printed flow chamber with integrated sensors for the monitoring of oral multispecies biofilm growthFrontiers in bioengineering and biotechnology · 2024Article
- Multispecies Bacterial Biofilms and Their Evaluation Using Bioreactors.Foods (Basel, Switzerland) · 2023Review
- Spatiotemporal monitoring of a periodontal multispecies biofilm model: demonstration of prebiotic treatment responses.Applied and environmental microbiology · 2023Article
- Rhamnolipid 89 Biosurfactant Is Effective againstInternational journal of molecular sciences · 2023Article
- Microbiologically influenced corrosion-more than just microorganisms.FEMS microbiology reviews · 2023Review
- Synergistic interactions in multispecies biofilm combinations of bacterial isolates recovered from diverse food processing industries.Frontiers in microbiology · 2023Article
- Clinically relevantBiofilm · 2022Review
- Application of Fluorescence In Situ Hybridization (FISH) in Oral Microbial Detection.Pathogens (Basel, Switzerland) · 2022Review
- Oral Microcosm Biofilms Grown under Conditions Progressing from Peri-Implant Health, Peri-Implant Mucositis, and Peri-Implantitis.International journal of environmental research and public health · 2022Article
- Adhesion Forces of Oral Bacteria to Titanium and the Correlation with Biophysical Cellular Characteristics.Bioengineering (Basel, Switzerland) · 2022Article
- Succession of oral bacterial colonizers on dental implant materials: An in vitro biofilm model.Dental materials : official publication of the Academy of Dental Materials · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peri-implant infections are the most common cause of implant failure in modern dental implantology. These are caused by the formation of biofilms on the implant surface and consist of oral commensal and pathogenic bacteria, which harm adjacent soft and hard tissues and may ultimately lead to implant loss. In order to improve the clinical situation, there has to be a better understanding of biofilm formation on abiotic surfaces. Therefore, we successfully developed a system to cultivate an oral multispecies biofilm model in a flow chamber system, optimized for the evaluation of biofilm formation on solid materials by direct microscopic investigation. The model contains four relevant oral bacterial species: Streptococcus oralis, Actinomyces naeslundii, Veillonella dispar and Porphyromonas gingivalis in ratios similar to the native situation. The reliability of the developed "Hanoverian Oral Multispecies Biofilm Implant Flow Chamber" (HOBIC) model was verified. Biofilm volume and live/dead distribution within biofilms were determined by fluorescence staining and confocal laser scanning microcopy (CLSM). The individual species distribution was analyzed using quantitative real time PCR with propidium monoazide pretreatment (PMA-qRT-PCR) and by urea-NaCl fluorescence in situ hybridization (urea-NaCl-FISH). This in vitro model may be used to analyze biofilm formation on dental implants in more detail and to develop future implant systems with improved material properties.
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