Evidence map›Paper›PMID 29771954›Full record

ArticlePloS one2018

Preoperative prediction of microvascular invasion of hepatocellular carcinoma with IVIM diffusion-weighted MR imaging and Gd-EOB-DTPA-enhanced MR imaging.

Wei Zhao, Wenguang Liu, Huaping Liu, Xiaoping Yi, Jiale Hou, Yigang Pei, Hui Liu, Deyun Feng, Liyu Liu, Wenzheng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei ZhaoDepartment of Radiology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.
Wenguang LiuDepartment of Radiology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.
Huaping LiuDepartment of Radiology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.
Xiaoping YiDepartment of Radiology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.
Jiale HouDepartment of Radiology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.
Yigang PeiDepartment of Radiology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.
Hui LiuDepartment of Radiology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.
Deyun FengDepartment of Pathology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.
Liyu LiuCenter for Molecular Medicine, Xiangya Hospital of Centre-South University, Changsha, Hunan, P.R. China.
Wenzheng LiDepartment of Radiology, Xiangya Hospital of Centre-south University, Changsha, Hunan, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microvascular invasion (MVI) is regarded as one of the independent risk factors for recurrence and poor prognosis of hepatocellular carcinoma (HCC). The presence of MVI in HCCs was evaluated on the basis of pathological reports of surgical specimens and was defined as tumor within a vascular space lined by endothelium that was visible only on microscopy. The aim of the study was to investigate the usefulness of intravoxel incoherent motion (IVIM) diffusion weighted (DW) magnetic resonance (MR) imaging in predicting MVI of HCC. Preoperative IVIM DW imaging and Gd-EOB-DTPA-enhanced MRI (DCE-MRI) of 51 patients were analyzed. Standard apparent diffusion coefficient (ADC), D (the true diffusion coefficient), D* (the pseudodiffusion coefficient) and f (the perfusion fraction), relative enhancement (RE) and radiological features were evaluated and analyzed. Univariate analysis revealed that HCCs with MVI had a higher portion of an irregular tumor shape than HCCs without MVI (p = 0.009), the Standard ADC, D value were significantly lower in HCCs with MVI (p = 0.022, p = 0.007, respectively). Multivariate analysis revealed that an irregular shape (p = 0.012) and D value ≤ 1.16×10-3mm2/sec (p = 0.048) were independent predictors for MVI. Combining the two factors of an irregular shape and D value, a sensitivity of 94.4% and specificity of 63.6% for predicting MVI was obtained. In conclusion, we found that an irregular shape and D value ≤ 1.16×10-3mm2/sec may suggest the presence of MVI in HCCs.

Indexed as

AdultAgedCarcinoma, HepatocellularContrast MediaDiffusion Magnetic Resonance ImagingFemaleGadolinium DTPAHumansLiver NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesYoung AdultContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPA

Identifiers

PMID29771954
PMCPMC5957402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.