ReviewCurrent opinion in pediatrics2018
Genetics of pubertal timing.
Review in Current opinion in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Morphological indicators of puberty in 3/4 and 5/8 Girolando heifers.Tropical animal health and production · 2026Article
- The Individual Relationship between Pubertal Growth and Physical Changes of Puberty in Healthy Adolescents.Hormone research in paediatrics · 2025Article
- Insights into pubertal development: a narrative review on the role of epigenetics.Journal of endocrinological investigation · 2025Review
- Deleterious variants in intolerant genes reveal new candidates for self-limited delayed puberty.European journal of endocrinology · 2025Article
- Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.Hormones (Athens, Greece) · 2025Review
- Editorial: Puberty: neurologic and physiologic development, volume II.Frontiers in endocrinology · 2025Article
- Novel variants ensued genomic imprinting in familial central precocious puberty.Journal of endocrinological investigation · 2024Article
- Study ofChildren (Basel, Switzerland) · 2024Article
- Behavioral and neural responses to social rejection: Individual differences in developmental trajectories across childhood and adolescence.Developmental cognitive neuroscience · 2024Article
- COVID-19 lockdown and the rate of central precocious puberty.Journal of endocrinological investigation · 2024Article
- Genetic and non-genetic factors in prediction of early pubertal development in Chinese girls.Frontiers in endocrinology · 2024Article
- Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty.Frontiers in endocrinology · 2024Review
- Endocrine Health and Health Care Disparities in the Pediatric and Sexual and Gender Minority Populations: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023Article
- [Gonadotropin-dependent precocious puberty: genetic and clinical characteristics].Problemy endokrinologii · 2023Article
- Neighborhood Racial and Economic Privilege and Timing of Pubertal Onset in Girls.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023Article
- Analysis of Early-Life Growth and Age at Pubertal Onset in US Children.JAMA network open · 2022Article
- Gene Polymorphisms Associated with Central Precocious Puberty and Hormone Levels in Chinese Girls.International journal of endocrinology · 2022Article
- Psychosocial and energetic factors on human female pubertal timing: a systematized review.Evolutionary human sciences · 2022Review
- Genetic and Epigenetic Control of Puberty.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022Review
- Adolescent Sport Participation and Age at Menarche in Relation to Midlife Body Composition, Bone Mineral Density, Fitness, and Physical Activity.Journal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewTo summarize advances in the genetics underlying variation in normal pubertal timing, precocious puberty, and delayed puberty, and to discuss mechanisms by which genes may regulate pubertal timing. RECENT
findingsGenome-wide association studies have identified hundreds of loci that affect pubertal timing in the general population in both sexes and across ethnic groups. Single genes have been implicated in both precocious and delayed puberty. Potential mechanisms for how these genetic loci influence pubertal timing may include effects on the development and function of the GnRH neuronal network and the responsiveness of end-organs. SUMMARY: There has been significant progress in identifying genetic loci that affect normal pubertal timing, and the first single-gene causes of precocious and delayed puberty are being described. How these genes influence pubertal timing remains to be determined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.