ArticleMolecular pharmaceutics2018
Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor.
Article in Molecular pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Metal-free nitroxide radical-based theranostic agent for MRI-guided therapy of ulcerative colitis.Materials today. Bio · 2026Article
- Designing Water-Soluble Macromolecules for Biomedical Use: PEG Chains versus Amino AcidsA Case Study in MRI Contrast Agents.ACS polymers Au · 2026Article
- Nitroxide-Based Contrast Agents for MRI Cancer Diagnostics: Progress, Limitations, and Perspectives.Molecules (Basel, Switzerland) · 2026Review
- Synthesis of sterically shielded piperidine nitroxides via acid-catalyzed heterocyclization of β-aminoketone derivatives with ketones.Beilstein journal of organic chemistry · 2026Article
- Semiconducting Polymer Nanoparticles as Multimodal Agents for Optical and Magnetic Resonance Imaging.Advanced healthcare materials · 2025Review
- Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals.Bioengineering (Basel, Switzerland) · 2024Review
- Pimonidazole-alkyne conjugate for sensitive detection of hypoxia by Cu-catalyzed click reaction.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Contrast Agents Based on Human Serum Albumin and Nitroxides forInternational journal of molecular sciences · 2024Article
- Plant Virus Nanoparticles Combat Cancer.Vaccines · 2023Review
- Uptake of Cell-Penetrating Peptide RL2 by Human Lung Cancer Cells: Monitoring by Electron Paramagnetic Resonance and Confocal Laser Scanning Microscopy.Molecules (Basel, Switzerland) · 2021Article
- Review
- A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence.Journal of nanobiotechnology · 2021Article
- Identification and physical characterization of a spontaneous mutation of the tobacco mosaic virus in the laboratory environment.Scientific reports · 2021Article
- Cell morphology-based machine learning models for human cell state classification.NPJ systems biology and applications · 2021Article
- Multimodal Functional Imaging for Cancer/Tumor Microenvironments Based on MRI, EPRI, and PET.Molecules (Basel, Switzerland) · 2021Review
- Nanotechnologies for Reactive Oxygen Species"Turn-On" Detection.Frontiers in bioengineering and biotechnology · 2021Review
- Plant Viruses and Bacteriophage-Based Reagents for Diagnosis and Therapy.Annual review of virology · 2020Review
- Pro-organic radical contrast agents ("pro-ORCAs") for real-time MRI of pro-drug activation in biological systems.Polymer chemistry · 2020Article
- Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents.Molecules (Basel, Switzerland) · 2020Article
- Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents.Chemical science · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Superoxide overproduction is known to occur in multiple disease states requiring critical care; yet, noninvasive detection of superoxide in deep tissue remains a challenge. Herein, we report a metal-free magnetic resonance imaging (MRI) and electron paramagnetic resonance (EPR) active contrast agent prepared by "click conjugating" paramagnetic organic radical contrast agents (ORCAs) to the surface of tobacco mosaic virus (TMV). While ORCAs are known to be reduced in vivo to an MRI/EPR silent state, their oxidation is facilitated specifically by reactive oxygen species-in particular, superoxide-and are largely unaffected by peroxides and molecular oxygen. Unfortunately, single molecule ORCAs typically offer weak MRI contrast. In contrast, our data confirm that the macromolecular ORCA-TMV conjugates show marked enhancement for T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.